Publications

Authors:

Martinelli, Nicola; García Heredia, A; Roca, H; Aranda, N; Arija, V; Mackness, B; Mackness, M; Busti, Fabiana; Aragonès, G; Pedro Botet, J; Pedica, Federica; Cataldo, Ivana; Marsillach, J; Joven, J; Girelli, D; Camps, J.

Title:

Paraoxonase-1 status in patients with hereditary hemochromatosis

Year:

2013

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

Sì

Name of journal:

Journal of Lipid Research

ISSN of journal:

0022-2275

N° Volume:

54

Number or Folder:

5

Page numbers:

1484-1492

Keyword:

antioxidants; inflammation; iron metabolism; oxidative stress

Short description of contents:

Hereditary hemochromatosis (HH) is characterized by accumulation of iron, oxidative stress, inflammation, and fibrogenesis in liver tissue. In this setting, research on the protection afforded by intracellular antioxidants is of clinical relevance. Paraoxonase-1 (PON1) is an enzyme that degrades lipid peroxides. This study investigates the alterations in serum PON1 status, PON1 gene polymorphisms, and PON1 hepatic expression in patients with HH. We performed a case-control study in 77 patients with HH (80.5% men, 22-70 years of age) and 408 healthy individuals (43.1% men, 26-74 years of age). Serum PON1 activities against different substrates and PON1192 and PON155 polymorphisms were analyzed. PON1 protein expression was investigated in 20 liver biopsies. HH patients had significantly lower serum PON1 activity, which was inversely correlated with ferritin (marker of iron stores) and serum 8-isoprostane concentrations (index of oxidative stress). PON1 protein expression in liver tissue was higher in patients and showed stronger staining in hepatocytes surrounding the areas of inflammation. Our study provides preliminary evidence that PON1 may play a role in protecting against iron-induced oxidative stress in hereditary hemochromatosis.

Product ID:

86158

Handle IRIS:

11562/653161

Deposited On:

February 23, 2015

Last Modified:

January 5, 2024

Bibliographic citation:

Martinelli, Nicola; García Heredia, A; Roca, H; Aranda, N; Arija, V; Mackness, B; Mackness, M; Busti, Fabiana; Aragonès, G; Pedro Botet, J; Pedica, Federica; Cataldo, Ivana; Marsillach, J; Joven, J; Girelli, D; Camps, J., Paraoxonase-1 status in patients with hereditary hemochromatosis «Journal of Lipid Research» , vol. 54 , n. 5 , 2013 , pp. 1484-1492

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