Publications

TIM-1 Glycoprotein Binds the Adhesion Receptor P-Selectin and Mediates T Cell Trafficking during Inflammation and Autoimmunity  (2014)

Authors:
Angiari S;Donnarumma T;Rossi B;Dusi, S.;Pietronigro E;Zenaro E;Della Bianca V;Toffali L;Piacentino G;Budui S;Rennert P;Xiao S;Laudanna C;Casasnovas JM;Kuchroo VK;Constantin G
Title:
TIM-1 Glycoprotein Binds the Adhesion Receptor P-Selectin and Mediates T Cell Trafficking during Inflammation and Autoimmunity
Year:
2014
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Referee:
Name of journal:
Immunity
ISSN of journal:
1074-7613
N° Volume:
40
Number or Folder:
4
Page numbers:
542-553
Keyword:
autoimmune disease; leukocyte trafficking; Selectins; T cell immunoglobulin; mucin domain 1 (TIM-1)
Short description of contents:
Selectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rolling of T helper 1 (Th1) and Th17, but not Th2 and regulatory T cells on P-selectin. Th1 and Th17 cells lacking the TIM-1 mucin domain showed reduced rolling in thrombin-activated mesenteric venules and inflamed brain microcirculation. Inhibition of TIM-1 had no effect on naive T cell homing, but it reduced T cell recruitment in a skin hypersensitivity model and blocked experimental autoimmune encephalomyelitis. Uniquely, the TIM-1 immunoglobulin variable domain was also required for P-selectin binding. Our data demonstrate that TIM-1 is a major P-selectin ligand with a specialized role in T cell trafficking during inflammatory responses and the induction of autoimmune disease.
Note:
pii: S1074-7613(14)00084-3
Product ID:
80461
Handle IRIS:
11562/703361
Deposited On:
July 17, 2014
Last Modified:
March 20, 2018
Bibliographic citation:
Angiari S;Donnarumma T;Rossi B;Dusi, S.;Pietronigro E;Zenaro E;Della Bianca V;Toffali L;Piacentino G;Budui S;Rennert P;Xiao S;Laudanna C;Casasnovas JM;Kuchroo VK;Constantin G, TIM-1 Glycoprotein Binds the Adhesion Receptor P-Selectin and Mediates T Cell Trafficking during Inflammation and Autoimmunity «Immunity» , vol. 40 , n. 42014pp. 542-553

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