Publications

Authors:

Gisondi, Paolo; Pezzolo, Elena; LO CASCIO, Giuliana; Girolomoni, Giampiero

Title:

Latent tuberculosis infection in patients with chronic plaque psoriasis who are candidates for biological therapy

Year:

2014

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

British Journal of Dermatology

ISSN of journal:

0007-0963

N° Volume:

171

Page numbers:

884-890

Keyword:

tuberculosis infection; plaque psoriasis; biological therapy

Short description of contents:

BackgroundScreening for latent tuberculosis infection (LTBI) is mandatory in patients with psoriasis prior to biological therapy.ObjectivesTo investigate the prevalence of LTBI in patients with psoriasis who are candidates for biological therapy.MethodsLTBI was investigated in patients with moderate-to-severe psoriasis (n = 243), Crohn disease (n = 64) or rheumatoid arthritis (RA) (n = 56) and in healthcare workers (n = 1683). LTBI diagnosis was based on positive QuantiFERON-B Gold In-Tube (QFT-GIT) in vitro assay without any clinical, radiological or microbiological evidence of active tuberculosis.ResultsLTBI was diagnosed in 8·2% of patients with psoriasis, 7% with Crohn disease and 9% with RA, and in 8·8% of healthcare workers (P = 0·9). Patients with psoriasis who also had LTBI (n = 20) received a 9-month prophylaxis with isoniazid (5 mg kg−1 daily). None of these patients developed active tuberculosis infection after receiving biological therapy (etanercept, adalimumab, infliximab or ustekinumab) for 37 ± 32 weeks (mean ± SD). All patients with psoriasis were retested for LTBI after 31 ± 1·7 months. Five of the 20 patients with LTBI presented QFT-GIT reversion and two patients out of 243 (0·8%) had QFT-GIT conversion and received antibiotic prophylaxis.ConclusionsThe prevalence of LTBI in patients with psoriasis is similar to that in patients with Crohn disease or RA and in healthcare workers. Prophylaxis with isoniazid is effective in preventing tuberculosis reactivation in patients with LTBI receiving biological therapy.

Product ID:

83333

Handle IRIS:

11562/809564

Deposited On:

October 23, 2014

Last Modified:

November 26, 2022

Bibliographic citation:

Gisondi, Paolo; Pezzolo, Elena; LO CASCIO, Giuliana; Girolomoni, Giampiero, Latent tuberculosis infection in patients with chronic plaque psoriasis who are candidates for biological therapy «British Journal of Dermatology» , vol. 171 , 2014 , pp. 884-890

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