Bone involvement and osteoporosis in mastocytosis.
Year:
2014
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
A Stampa
Referee:
Sì
Name of journal:
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
ISSN of journal:
0889-8561
N° Volume:
34
Number or Folder:
2
Page numbers:
383-396
Keyword:
mastocytosis; osteoporosis; bisphosphonate
Short description of contents:
Bone involvement is frequent in patients with systemic mastocytosis. Osteoporosis is the most prevalent bone manifestation, but diffuse osteosclerosis or focal osteolytic or osteosclerotic lesions are not infrequent. The risk of osteoporotic fractures is high, especially at the spine and in men. Routine measurements of bone mineral density and vertebral morphometry are warranted. The bone turnover markers indicate the involvement of complex bone metabolism in mastocytosis-related manifestations. Bisphosphonates represent the first-line treatment for osteoporosis-related mastocytosis.