Publications

Authors:

Ricci, C.; D'Alessandro, D.; Ugel, Stefano; Sartoris, Silvia; Bronte, Vincenzo; Moroni, L.; Danti, S.

Title:

Interaction of human pancreatic ductal adenocarcinoma cells with polymeric scaffolds to develop tissue-engineered cancer models.

Year:

2013

Type of item:

Abstract in rivista

Tipologia ANVUR:

Abstract su rivista

Language:

Inglese

Format:

A Stampa

Keyword:

gelatin; molecular scaffold; polycaprolactone; polymer; cancer cell; cancer growth; cancer model; cell infiltration; cell interaction; cell structure; cell viability; cellular distribution; electrospinning; human; human cell; pancreas adenocarcinoma; scanning electron microscopy; thickness; tissue engineering

Short description of contents:

Pancreatic Ductal Adenocarcinoma (PDAC) is a fatal neoplasia of the exocrine pancreas with a high mortality rate. PDAC microenvironment is heterogeneous and has been found to play a crucial role in carcinogenesis and negative response to treatments. Moreover, early biomarkers are missing. Biomimetic models of PDAC are thus desirable to understand the underlying molecular mechanisms and to approach new therapies. In this view, the development of 3D tumor models via tissue engineering can offer valuable opportunities . The aim of this study was to investigate the interactions between PDAC cells and different scaffolds to generate new 3D in vitro models for the study of tumor growth and development.

Product ID:

86378

Handle IRIS:

11562/903183

Deposited On:

March 12, 2015

Last Modified:

November 15, 2022

Bibliographic citation:

Ricci, C.; D'Alessandro, D.; Ugel, Stefano; Sartoris, Silvia; Bronte, Vincenzo; Moroni, L.; Danti, S., Interaction of human pancreatic ductal adenocarcinoma cells with polymeric scaffolds to develop tissue-engineered cancer models. 2013

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo