Publications

Authors:

Scrutinio, Domenico; Agostoni, Piergiuseppe; Gesualdo, Loreto; Corrà, Ugo; Mezzani, Alessandro; Piepoli, Massimo; Di Lenarda, Andrea; Iorio, Annamaria; Passino, Claudio; Magrì, Damiano; Masarone, Daniele; Battaia, Elisa; Girola, Davide; Re, Federica; Cattadori, Gaia; Parati, Gianfranco; Sinagra, Gianfranco; Villani, Giovanni Quinto; Limongelli, Giuseppe; Pacileo, Giuseppe; Guazzi, Marco; Metra, Marco; Frigerio, Maria; Cicoira, Mariantonietta; Minà, Chiara; Malfatto, Gabriella; Caravita, Sergio; Bussotti, Maurizio; Salvioni, Elisabetta; Veglia, Fabrizio; Correale, Michele; Scardovi, Angela B; Emdin, Michele; Giannuzzi, Pantaleo; Gargiulo, Paola; Giovannardi, Marta; Perrone Filardi, Pasquale; Raimondo, Rosa; Ricci, Roberto; Paolillo, Stefania; Farina, Stefania; Belardinelli, Romualdo; Passantino, Andrea; La Gioia, Rocco

Title:

Renal function and peak exercise oxygen consumption in chronic heart failure with reduced left ventricular ejection fraction

Year:

2015

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

CIRCULATION JOURNAL

ISSN of journal:

1346-9843

N° Volume:

79

Number or Folder:

3

Page numbers:

583-591

Keyword:

heart failure, exercise capacity, renal function

Short description of contents:

Chronic kidney disease is associated with sympathetic activation and muscle abnormalities, which may contribute to decreased exercise capacity. We investigated the correlation of renal function with peak exercise oxygen consumption (V̇O2) in heart failure (HF) patients. METHODS AND RESULTS: We recruited 2,938 systolic HF patients who underwent clinical, laboratory, echocardiographic and cardiopulmonary exercise testing. The patients were stratified according to estimated glomerular filtration rate (eGFR). Mean follow-up was 3.7 years. The primary outcome was a composite of cardiovascular death and urgent heart transplantation at 3 years. On multivariable regression, eGFR was predictor of peakV̇O2(P<0.0001). Other predictors were age, sex, body mass index, HF etiology, NYHA class, atrial fibrillation, resting heart rate, B-type natriuretic peptide, hemoglobin, and treatment. After adjusting for significant covariates, the hazard ratio for primary outcome associated with peakV̇O2<12 ml·kg(-1)·min(-1)was 1.75 (95% confidence interval (CI): 1.06-2.91; P=0.0292) in patients with eGFR ≥60, 1.77 (0.87-3.61; P=0.1141) in those with eGFR of 45-59, and 2.72 (1.01-7.37; P=0.0489) in those with eGFR <45 ml·min(-1)·1.73 m(-2). The area under the receiver-operating characteristic curve for peakV̇O2<12 ml·kg(-1)·min(-1)was 0.63 (95% CI: 0.54-0.71), 0.67 (0.56-0.78), and 0.57 (0.47-0.69), respectively. Testing for interaction was not significant.

Product ID:

88196

Handle IRIS:

11562/927113

Last Modified:

November 15, 2022

Bibliographic citation:

Scrutinio, Domenico; Agostoni, Piergiuseppe; Gesualdo, Loreto; Corrà, Ugo; Mezzani, Alessandro; Piepoli, Massimo; Di Lenarda, Andrea; Iorio, Annamaria; Passino, Claudio; Magrì, Damiano; Masarone, Daniele; Battaia, Elisa; Girola, Davide; Re, Federica; Cattadori, Gaia; Parati, Gianfranco; Sinagra, Gianfranco; Villani, Giovanni Quinto; Limongelli, Giuseppe; Pacileo, Giuseppe; Guazzi, Marco; Metra, Marco; Frigerio, Maria; Cicoira, Mariantonietta; Minà, Chiara; Malfatto, Gabriella; Caravita, Sergio; Bussotti, Maurizio; Salvioni, Elisabetta; Veglia, Fabrizio; Correale, Michele; Scardovi, Angela B; Emdin, Michele; Giannuzzi, Pantaleo; Gargiulo, Paola; Giovannardi, Marta; Perrone Filardi, Pasquale; Raimondo, Rosa; Ricci, Roberto; Paolillo, Stefania; Farina, Stefania; Belardinelli, Romualdo; Passantino, Andrea; La Gioia, Rocco, Renal function and peak exercise oxygen consumption in chronic heart failure with reduced left ventricular ejection fraction «CIRCULATION JOURNAL» , vol. 79 , n. 3 , 2015 , pp. 583-591

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