Pubblicazioni

Autori:

DE MARCHI, Sergio; Garbin, Ulisse; Rigoni, A.; Stranieri, Chiara; Rulfo, F.; Prior, Manlio; Arosio, Enrico

Titolo:

IMROVEMENT OF OXIDATIVE DEFENSIVE PATHWAYS AND INFLAMMATION IN PERIPHERAL ARTERY DISEASE AFTER SUPERVISED TRAINING

Anno:

2016

Tipologia prodotto:

Poster

Tipologia ANVUR:

Poster

Lingua:

Inglese

Formato:

Elettronico

Titolo del Convegno:

European Society of Vascular Medicine - second annual congress

Luogo:

Roma

Periodo:

8-10 maggio 2016

Intervallo pagine:

48-48

Parole chiave:

training , peripheral arterial disease, oxydative stress, monocytes

Breve descrizione dei contenuti:

Recent evidences suggest that exercise training may improve oxidative stress in patients with peripheral arterial disease (PAD) and reduce inflammation. Few data are available on mechanisms involved. Nuclear related factor 2 (Nrf2), regulates the expression of antioxidant enzymes and proteins through the antioxidant response ; Nrf2 is also involved in protection against oxidative stress during the processes of ischemia-reperfusion injury , phenomenon that is elicited during claudication pain. Also monocytes (CD16+) are recognized as an important actor in aterosclerosis expecially for progression of plaques and inflammatory damage. We aimed to evaluate in PAD the effects of controlled exercise training on oxidative stress, Nrf2 gene expression and monocyte subsets.Our study shows that training in PAD patients improves walking time, furthermore it reduces oxidative stress (decrease of MDA) and increases anti-oxidative defensive system enhancing Nrf2-gene expression. The training elicited multiple episodes of ischemia-reperfusion every day and, since Nrf2 is involved in protecting from ischemia-reperfusion injury we can infer that somehow we "trained" also Nrf2 system. The shift of monocytes subtype from an inflammatory to a classic subtype suggests a deep change in inflammation profile of these patients with training.

Id prodotto:

91931

Handle IRIS:

11562/941681

ultima modifica:

25 ottobre 2022

Citazione bibliografica:

DE MARCHI, Sergio; Garbin, Ulisse; Rigoni, A.; Stranieri, Chiara; Rulfo, F.; Prior, Manlio; Arosio, Enrico, IMROVEMENT OF OXIDATIVE DEFENSIVE PATHWAYS AND INFLAMMATION IN PERIPHERAL ARTERY DISEASE AFTER SUPERVISED TRAINING  in ESVM congress programme , Atti di "European Society of Vascular Medicine - second annual congress" , Roma , 8-10 maggio 2016 , 2016 , pp. 48-48

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