Publications

Authors:

Giacomelli, Mauro; Kumar, Rajesh; Soresina, Annarosa; Tamassia, Nicola; Lorenzini, Tiziana; Moratto, Daniele; Gasperini, Sara; Cassatella, Marco Antonio; Plebani, Alessandro; Lougaris, Vassilios; Badolato, Raffaele

Title:

Reduction of CRKL expression in patients with partial DiGeorge syndrome is associated with impairment of T-cell functions

Year:

2016

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

Journal of Allergy and Clinical Immunonology

ISSN of journal:

0091-6749

N° Volume:

138

Number or Folder:

1

:

Elsevier Science

Page numbers:

229-240

Keyword:

CRKL; DiGeorge syndrome; IL-2; T-cell receptor activation; c-Fos; proliferation; signal transducer and activator of transcription 5

Short description of contents:

Partial DiGeorge syndrome (pDGS) is caused by deletion of the 22q11.2 region. Within this region lies CrK-like (CRKL), a gene encoding an adapter protein belonging to the Crk family that is involved in the signaling cascade of IL-2, stromal cell-derived factor 1α, and type I interferon. Although recurrent infections can be observed in patients with deletion of chromosome 22 syndrome, the immune pathogenesis of this condition is yet not fully understood.

Product ID:

94158

Handle IRIS:

11562/952205

Last Modified:

November 15, 2022

Bibliographic citation:

Giacomelli, Mauro; Kumar, Rajesh; Soresina, Annarosa; Tamassia, Nicola; Lorenzini, Tiziana; Moratto, Daniele; Gasperini, Sara; Cassatella, Marco Antonio; Plebani, Alessandro; Lougaris, Vassilios; Badolato, Raffaele, Reduction of CRKL expression in patients with partial DiGeorge syndrome is associated with impairment of T-cell functions «Journal of Allergy and Clinical Immunonology» , vol. 138 , n. 1 , 2016 , pp. 229-240

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