HEPCIDIN REPRESSION BY PROMOTER DNA HYPERMETHYLATION IN NON-VIRAL HEPATOCELLULAR CARCINOMA
Year:
2016
Type of item:
Abstract in rivista
Tipologia ANVUR:
Abstract su rivista
Language:
Inglese
Format:
A Stampa
Keyword:
Epigenetics, hepcidin, DNA methylation, HAMP gene, iron metabolism, ferritin, primary liver cancer, hepatocellular carcinoma
Short description of contents:
Hepcidin is an hormone that regulates iron metabolism and this study highlight for the first time that the gene encoding for hepcidin, HAMP, is regulated transcriptionally by a major epigenetic mechanism, DNA methylation at promoter site.