Publications

Authors:

Mariotto, S; Farinazzo, A; Monaco, S; Gajofatto, A; Zanusso, G; Schanda, K; Capra, R; Mancinelli, C; Bonora, A; Bombardi, R; Reindl, M; Ferrari, S

Title:

Serum Neurofilament Light Chain in NMOSD and Related Disorders: Comparison According to Aquaporin-4 and Myelin Oligodendrocyte Glycoprotein Antibodies Status

Year:

2017

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

MULTIPLE SCLEROSIS JOURNAL, EXPERIMENTAL, TRANSLATIONAL AND CLINICAL

ISSN of journal:

2055-2173

N° Volume:

3

Number or Folder:

4

Page numbers:

1-4

Keyword:

Neurofilament light chain; aquaporin-4; myelin oligodendrocyte glycoprotein; myelitis; neuromyelitis optica (NMOSD); optic neuritis

Short description of contents:

Background: Neurofilament light chain (NF-L) levels reflect axonal damage in different conditions, including demyelinating disorders. Objectives: We aimed to compare serum NF-L levels in patients with aquaporin-4 antibodies (AQP4-Ab), myelin oligodendrocyte antibodies (MOG-Ab) and seronegative cases with neuromyelitis optica spectrum disorders and related disorders. Methods: We analysed AQP4-Ab and MOG-Ab with cell-based assay and NF-L with ultrasensitive electrochemiluminescence immunoassay. Results: Median NF-L levels were increased in 25 AQP4-Ab-positive patients (59 pg/ml) as compared with 22 MOG-Ab-positive cases (25 pg/ml), 52 seronegative patients (18 pg/ml), 25 multiple sclerosis patients (12 pg/ml) and 14 healthy controls (12 pg/ml). Conclusions: Increased serum levels of NF-L in patients with AQP4-Ab or MOG-Ab might reflect an ongoing axonal damage and a more malignant disease course.

Web page:

https://doi.org/10.1177/2055217317743098

Product ID:

99607

Handle IRIS:

11562/971148

Last Modified:

November 15, 2022

Bibliographic citation:

Mariotto, S; Farinazzo, A; Monaco, S; Gajofatto, A; Zanusso, G; Schanda, K; Capra, R; Mancinelli, C; Bonora, A; Bombardi, R; Reindl, M; Ferrari, S, Serum Neurofilament Light Chain in NMOSD and Related Disorders: Comparison According to Aquaporin-4 and Myelin Oligodendrocyte Glycoprotein Antibodies Status «MULTIPLE SCLEROSIS JOURNAL, EXPERIMENTAL, TRANSLATIONAL AND CLINICAL» , vol. 3 , n. 4 , 2017 , pp. 1-4

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