Inhibition of Pseudomonas aeruginosa secreted virulence factors reduces lung inflammation in CF mice
Anno:
2018
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Formato:
A Stampa
Referee:
Sì
Nome rivista:
VIRULENCE
ISSN Rivista:
2150-5594
N° Volume:
9
Numero o Fascicolo:
1
Intervallo pagine:
1008-1018
Parole chiave:
Cystic fibrosis; Pseudomonas aeruginosa; clarithromycin; in vivo imaging; lung inflammation; protease inhibitors; virulence factors
Breve descrizione dei contenuti:
Cystic fibrosis (CF) lung infection is a complex condition where opportunistic pathogens and defective immune system cooperate in developing a constant cycle of infection and inflammation. The major pathogen, Pseudomonas aeruginosa, secretes a multitude of virulence factors involved in host immune response and lung tissue damage. In this study, we examined the possible anti-inflammatory effects of molecules inhibiting P. aeruginosa virulence factors.