Pubblicazioni

Autori:

Danese, Elisa; Raimondi, Sara; Montagnana, Martina; Tagetti, Angela; Langaee, Taimour; Borgiani, Paola; Ciccacci, Cinzia; Carcas, Antonio J; Borobia, Alberto M; Tong, Hoi Y; Dávila-Fajardo, Cristina; Botton, Mariana Rodrigues; Bourgeois, Stephane; Deloukas, Panos; Caldwell, Michael D; Burmester, Jim K; Berg, Richard L; Cavallari, Larisa H; Drozda, Katarzyna; Huang, Min; Zhao, Li-Zi; Cen, Han-Jing; Gonzalez-Conejero, Rocio; Roldan, Vanessa; Nakamura, Yusuke; Mushiroda, Taisei; Gong, Inna Y; Kim, Richard B; Hirai, Keita; Itoh, Kunihiko; Isaza, Carlos; Beltrán, Leonardo; Jiménez-Varo, Enrique; Cañadas-Garre, Marisa; Giontella, Alice; Kringen, Marianne Kristiansen; Bente Foss Haug, Kari; Gwak, Hye Sun; Lee, Kyung Eun; Minuz, Pietro; Lee, Ming Ta Michael; Lubitz, Steven A; Scott, Stuart; Mazzaccara, Cristina; Sacchetti, Lucia; Genç, Ece; Özer, Mahmut; Pathare, Anil; Krishnamoorthy, Rajagopal; Paldi, Andras; Siguret, Virginie; Loriot, Marie-Anne; Kutala, Vijay Kumar; Suarez-Kurtz, Guilherme; Perini, Jamila; Denny, Josh C; Ramirez, Andrea H; Mittal, Balraj; Rathore, Saurabh Singh; Sagreiya, Hersh; Altman, Russ; Shahin, Mohamed Hossam A; Khalifa, Sherief I; Limdi, Nita A; Rivers, Charles; Shendre, Aditi; Dillon, Chrisly; Suriapranata, Ivet M; Zhou, Hong-Hao; Tan, Sheng-Lan; Tatarunas, Vacis; Lesauskaite, Vaiva; Zhang, Yumao; Maitland-van der Zee, Anke H; Verhoef, Talitha I; de Boer, Anthonius; Taljaard, Monica; Zambon, Carlo Federico; Pengo, Vittorio; Zhang, Jieying Eunice; Pirmohamed, Munir; Johnson, Julie A; Fava, Cristiano

Titolo:

The effect of CYP4F2, VKORC1 and CYP2C9 in influencing coumarin dose. A single patient data meta-analysis in more than 15,000 individuals

Anno:

2019

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

International Journal of Clinical Pharmacology and Therapeutics

ISSN Rivista:

0009-9236

N° Volume:

105

Numero o Fascicolo:

6

Intervallo pagine:

1477-1491

Parole chiave:

CYP2C9; CYP4F2; VKORC1; coumarin drugs; meta-analysis; pharmacogenetics; predictive models

Breve descrizione dei contenuti:

The CYP4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at individual patients' level to capture the possible effect of ethnicity, gene-gene interaction or other drugs on the association and to verify if inclusion of CYP4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta-analysis (30 articles) and of 38 new articles retrieved by a systematic review to send us individual patients' data. The final collection consists 15,754 patients split into a derivation and validation cohort. The CYP4F2*3 polymorphism was consistently associated with an increase in mean coumarin dose (+9% (95%CI 7-10%), with a higher effect in females, in patients taking acenocoumarol and in Whites. The inclusion of the CYP4F2*3 in dosing algorithms slightly improved the prediction of stable coumarin dose. New pharmacogenetic equations potentially useful for clinical practice were derived. This article is protected by copyright. All rights reserved.

Note:

Elisa Danese and Sara Raimondi contributed equally to the work. Julie A. Johnson and Cristiano Fava contributed equally to the work.

Pagina Web:

https://doi.org/10.1002/cpt.1323

Id prodotto:

105478

Handle IRIS:

11562/988361

ultima modifica:

12 novembre 2022

Citazione bibliografica:

Danese, Elisa; Raimondi, Sara; Montagnana, Martina; Tagetti, Angela; Langaee, Taimour; Borgiani, Paola; Ciccacci, Cinzia; Carcas, Antonio J; Borobia, Alberto M; Tong, Hoi Y; Dávila-Fajardo, Cristina; Botton, Mariana Rodrigues; Bourgeois, Stephane; Deloukas, Panos; Caldwell, Michael D; Burmester, Jim K; Berg, Richard L; Cavallari, Larisa H; Drozda, Katarzyna; Huang, Min; Zhao, Li-Zi; Cen, Han-Jing; Gonzalez-Conejero, Rocio; Roldan, Vanessa; Nakamura, Yusuke; Mushiroda, Taisei; Gong, Inna Y; Kim, Richard B; Hirai, Keita; Itoh, Kunihiko; Isaza, Carlos; Beltrán, Leonardo; Jiménez-Varo, Enrique; Cañadas-Garre, Marisa; Giontella, Alice; Kringen, Marianne Kristiansen; Bente Foss Haug, Kari; Gwak, Hye Sun; Lee, Kyung Eun; Minuz, Pietro; Lee, Ming Ta Michael; Lubitz, Steven A; Scott, Stuart; Mazzaccara, Cristina; Sacchetti, Lucia; Genç, Ece; Özer, Mahmut; Pathare, Anil; Krishnamoorthy, Rajagopal; Paldi, Andras; Siguret, Virginie; Loriot, Marie-Anne; Kutala, Vijay Kumar; Suarez-Kurtz, Guilherme; Perini, Jamila; Denny, Josh C; Ramirez, Andrea H; Mittal, Balraj; Rathore, Saurabh Singh; Sagreiya, Hersh; Altman, Russ; Shahin, Mohamed Hossam A; Khalifa, Sherief I; Limdi, Nita A; Rivers, Charles; Shendre, Aditi; Dillon, Chrisly; Suriapranata, Ivet M; Zhou, Hong-Hao; Tan, Sheng-Lan; Tatarunas, Vacis; Lesauskaite, Vaiva; Zhang, Yumao; Maitland-van der Zee, Anke H; Verhoef, Talitha I; de Boer, Anthonius; Taljaard, Monica; Zambon, Carlo Federico; Pengo, Vittorio; Zhang, Jieying Eunice; Pirmohamed, Munir; Johnson, Julie A; Fava, Cristiano, The effect of CYP4F2, VKORC1 and CYP2C9 in influencing coumarin dose. A single patient data meta-analysis in more than 15,000 individuals «International Journal of Clinical Pharmacology and Therapeutics» , vol. 105 , n. 6 , 2019 , pp. 1477-1491

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