Development of a new anti-inflammatory pharmacological approach for the treatment of septic shock

Data inizio
1 settembre 2006
Durata (mesi) 
12
Responsabili (o referenti locali)
Laudanna Carlo
Parole chiave
Septic shock, Leukocyte recruitment, Cytokine, Oxidative stress, Signal transduction

  1. Identification and characterization of novel V-ATPases inhibitors able to interfere adhesive and pro-inflammatory activities of leukocytes in in vitro assays.
    1. Effect of V-ATPase inhibitors on rapid integrin activation and dependent adhesion
    2. Effect of V-APTase inhibitors on chemotaxis
    3. Effect of V-APTase inhibitors on generation of oxygen free-radicals (oxidative stress)
    4. Effect of V-ATPase inhibitors on pro-inflammatory cytokine production
  2. Pharmacological characterization of the capability of V-ATPases inhibitors onset and/or to reduce the severity of septic shock in animal models.
    1. Effect of V-ATP-ase inhibitors on onset and progression of septic shock
    2. Identification of compound-related activity, best dosage and toxic effect

Enti finanziatori:

Finanziamento: assegnato e gestito dal Dipartimento

Partecipanti al progetto

Simone Dorothea Bach
Matteo Bolomini Vittori
Gabriela Constantin
Professore ordinario
Cinzia Giagulli
Carlo Laudanna
Professore ordinario
Marianna Martinello
Barbara Rossi

Attività

Strutture