Pubblicazioni

Autori:

Paolino, Gaetano; Basturk, Olca; Esposito, Irene; Hong, Seung-Mo; Brosens, Lodewijk A; Tarcan, Zeynep; Wood, Laura D; Gkountakos, Anastasios; Omori, Yuko; Mattiolo, Paola; Ciulla, Calogero; Marchegiani, Giovanni; Pea, Antonio; Bevere, Michele; De Robertis, Riccardo; D'Onofrio, Mirko; Salvia, Roberto; Cheng, Liang; Furukawa, Toru; Scarpa, Aldo; Adsay, Volkan; Luchini, Claudio

Titolo:

Comprehensive characterization of intraductal oncocytic papillary neoplasm of the pancreas: a systematic and critical review

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

No

Nome rivista:

Modern Pathology

ISSN Rivista:

0893-3952

N° Volume:

37

Numero o Fascicolo:

9

Intervallo pagine:

1-12

Parole chiave:

IOPN; IPMN; Intraductal; PRKACA; PRKACB; oncocytic; oxyphilic; pancreatic cancer

Breve descrizione dei contenuti:

: Intraductal oncocytic papillary neoplasm (IOPN) of the pancreas is a recently recognized pancreatic tumor. Here, we aimed to determine the most essential features with the systematic review tool. PubMed, SCOPUS, and Embase were searched for studies reporting data on pancreatic IOPN. The clinicopathological, immunohistochemical, and molecular data were extracted and summarized. Then, a comparative analysis of the molecular alterations of IOPN with those of pancreatic ductal adenocarcinoma and intraductal papillary mucinous neoplasm from reference cohorts (including The Cancer Genome Atlas) was conducted. The key findings from 414 IOPNs were as follows: 1) Clinicopathological Features: Male-to-female ratio was 1,5:1. Pancreatic head was the most common site (131/237, 55.3%), but a diffuse tumor extension involving more than one pancreatic segment was described in about 1/5 of cases (49/237, 20.6%). The mean size was 45.5 mm. An associated invasive carcinoma was present in 50% of cases (168/336). In those cases, most tumors were pT1/pT2 and pN0 (>80%), and vascular invasion was uncommon (20.6%). Regarding survival, more than 90% of patients were alive after surgical resection. 2) Immunohistochemical and Molecular Features: The most expressed mucins were MUC5AC (110/112, 98.2%) and MUC6 (78/84, 92.8%). Compared with pancreatic ductal adenocarcinoma and intraductal papillary mucinous neoplasm, the classic pancreatic drivers KRAS, TP53, CDKN2A, SMAD4, and GNAS were less altered in IOPN (p<0.01). Moreover, fusions involving PRKACA or PRKACB genes were detected in all of 68 cases examined, with PRKACB::ATP1B1 as the most common (27/68 cases, 39.7%). These genomic events emerged as an entity-defining molecular alteration of IOPN (p<0.01). Thus, such fusions represent a promising biomarker for diagnostic purposes. Recent evidence also suggests their role in influencing the acquisition of oncocytic morphology. IOPN is a distinct pancreatic neoplasm with specific clinicopathological and molecular features. Considering the clinical/prognostic implications, its recognition is essential for pathologists and, ultimately, patients' management.

Note:

Available online 29 June 2024

Id prodotto:

140392

Handle IRIS:

11562/1130308

ultima modifica:

21 agosto 2024

Citazione bibliografica:

Paolino, Gaetano; Basturk, Olca; Esposito, Irene; Hong, Seung-Mo; Brosens, Lodewijk A; Tarcan, Zeynep; Wood, Laura D; Gkountakos, Anastasios; Omori, Yuko; Mattiolo, Paola; Ciulla, Calogero; Marchegiani, Giovanni; Pea, Antonio; Bevere, Michele; De Robertis, Riccardo; D'Onofrio, Mirko; Salvia, Roberto; Cheng, Liang; Furukawa, Toru; Scarpa, Aldo; Adsay, Volkan; Luchini, Claudio, Comprehensive characterization of intraductal oncocytic papillary neoplasm of the pancreas: a systematic and critical review «Modern Pathology» , vol. 37 , n. 9 , 2024 , pp. 1-12

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo