Detection of drug-induced signatures in normal and in tumour cells by Fourier Transform InfraRed Microspectroscopy (FTIRM).

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  4. Detection of drug-induced signatures in normal and in tumour cells by Fourier Transform InfraRed Microspectroscopy (FTIRM).
Data inizio
29 febbraio 2008
Durata (mesi) 
12
Responsabili (o referenti locali)
Bellisola Giuseppe

To identify early biochemical and morphological effects of anticancer drugs targeting intracellular signaling networks by FTIRM at single cell and sub-cellular levels. To develop procedures and optimize instrumental setup for the potential application of FTIRM to pre-clinical drug screening assays in cell models and to identify drug-resistant cancer cell subpopulations in leukaemic patients.

Partecipanti al progetto

Giuseppe Bellisola
Gabriella Bergamini
Carlo Laudanna
Professore ordinario
Claudio Sorio
Professore associato

Collaboratori esterni

Lisa Vaccari
Elettra Synchrotron Light Source Trieste IR beamline SISSI
Giovanni Birarda
Elettra Synchrotron Light Source Trieste IR beamline SISSI
Pubblicazioni
Titolo Autori Anno
Development of FT-IR microspectroscopy for pre-clinical and clinical applications Bellisola, Giuseppe; Bergamini, Corinna; BOLOMINI VITTORI, Matteo; Cestelli Guidi, M.; Cinque, G.; DELLA PERUTA, Marco; Giagulli, Cinzia; Laudanna, Carlo; Mafficini, Andrea; Marcelli, A.; Melotti, Paola Maria; Piccinini, M.; Sorio, Claudio 2008

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