Pubblicazioni

Autori:

Mourad, Jj; Agnoletti, D; Labat, C; Gautier, S; Salvi, P; Valbusa, F; Hanon, O; Toulza, O; Manckoundia, P; Fantin, F; Rolland, Y; Benetos, A

Titolo:

Interest of Combined Blood Pressure Measurements in Very Old Frail Subjects: The PARTAGE Study

Anno:

2018

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

American Journal of Hypertension

ISSN Rivista:

0895-7061

N° Volume:

31

Numero o Fascicolo:

8

Intervallo pagine:

950-956

Parole chiave:

frailty; pulse pressure amplification; blood pressure; mortality; orthostatic hypertension; Antihypertensive Drugs; orthiostatic hypotension

Breve descrizione dei contenuti:

BACKGROUNDSeveral clinical studies have shown that blood pressure (BP) measurements in very old frail individuals are of limited interest due to the fact that several age-related alterations and geriatric syndromes may modify BP. We studied in persons over 80-year old living in nursing homes the combined effects of 3 BP patterns on total mortality and major cardiovascular (CV) events: (i) low pulse pressure amplification (L-PPA) between carotid and brachial artery, (ii) systolic BP (SBP) < 130 mm Hg (L-SBP), under > 1 antihypertensive drugs, and (iii) changes in SBP between supine and upright position of > 20 mm Hg in both directions (hypotension/hypertension, orthostatic SBP [O-SBP]).METHODSThis analysis was performed in subjects of the PARTAGE study presenting all these 3 measurements (n = 883). The combined effects of L-PPA, L-SBP, and O-SBP were studied during the 2 years followed-up period.RESULTSAfter adjusting for age, sex, and history of CV events, all 3 BP patterns were independent determinants of major CV events (L-PPA, (P = 0.023); SBP, (P = 0.050); O-SBP, (P = 0.015)), whereas L-PPA (P = 0.012) and L-SBP (P = 0.006) were also independent determinants of total mortality. Compared with the subjects without any BP pattern, the presence of 2 or 3 BP patterns was associated with an increase in total mortality and major CV events greater than 2 and 2.5 times, respectively.CONCLUSIONSIn very old frail subjects, there is a particular interest for using different BP measurement approaches, than in younger populations, in order to evaluate the risks related to the BP levels.

Id prodotto:

115222

Handle IRIS:

11562/1020607

ultima modifica:

11 novembre 2022

Citazione bibliografica:

Mourad, Jj; Agnoletti, D; Labat, C; Gautier, S; Salvi, P; Valbusa, F; Hanon, O; Toulza, O; Manckoundia, P; Fantin, F; Rolland, Y; Benetos, A, Interest of Combined Blood Pressure Measurements in Very Old Frail Subjects: The PARTAGE Study «American Journal of Hypertension» , vol. 31 , n. 8 , 2018 , pp. 950-956

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