Pubblicazioni

Autori:

Vanoli, Alessandro; Grillo, Federica; Guerini, Camilla; Neri, Giuseppe; Arpa, Giovanni; Klersy, Catherine; Nesi, Gabriella; Giuffrida, Paolo; Sampietro, Gianluca; Ardizzone, Sandro; Fociani, Paolo; Fiocca, Roberto; Latella, Giovanni; Sessa, Fausto; D'Errico, Antonietta; Malvi, Deborah; Mescoli, Claudia; Rugge, Massimo; Ferrero, Stefano; Poggioli, Gilberto; Rizzello, Fernando; Macciomei, Maria C; Santini, Donatella; Volta, Umberto; De Giorgio, Roberto; Caio, Giacomo; Calabrò, Antonio; Ciacci, Carolina; D'Armiento, Maria; Rizzo, Aroldo; Solina, Gaspare; Martino, Michele; Tonelli, Francesco; Villanacci, Vincenzo; Cannizzaro, Renato; Canzonieri, Vincenzo; Florena, Ada Maria; Biancone, Livia; Monteleone, Giovanni; Caronna, Roberto; Ciardi, Antonio; Elli, Luca; Caprioli, Flavio; Vecchi, Maurizio; D'Incà, Renata; Zingone, Fabiana; D'Odorico, Anna; Lenti, Marco Vincenzo; Oreggia, Barbara; Reggiani Bonetti, Luca; Giannone, Antonino Giulio; Orlandi, Augusto; Barresi, Valeria; Ciccocioppo, Rachele; Amodeo, Giuseppe; Biletta, Elena; Luinetti, Ombretta; Pedrazzoli, Paolo; Pietrabissa, Andrea; Corazza, Gino Roberto; Solcia, Enrico; Paulli, Marco; Di Sabatino, Antonio

Titolo:

Prognostic Role of Mismatch Repair Status, Histotype and High-Risk Pathologic Features in Stage II Small Bowel Adenocarcinomas

Anno:

2021

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

No

Nome rivista:

ANNALS OF SURGICAL ONCOLOGY

ISSN Rivista:

1068-9265

N° Volume:

28

Numero o Fascicolo:

2

Intervallo pagine:

1167-1177

Parole chiave:

COLORECTAL-CANCER; CARCINOMAS; CONSENSUS

Breve descrizione dei contenuti:

Background. Small bowel adenocarcinoma is a relatively rare cancer, often diagnosed in an advanced stage. In localized and resectable disease, surgery alone or in combination with adjuvant chemotherapy is the mainstay of treatment. In the recently published National Comprehensive Cancer Network Clinical Practice guidelines, criteria for selecting patients with stage II small bowel adenocarcinoma to receive adjuvant chemotherapy are provided, and they are mainly extrapolated from studies on colorectal cancer.Patients and Methods. In the present study, we aimed to verify whether mismatch repair deficiency phenotype, high-risk pathologic features (including T4, positive resection margins and a low number of lymph nodes harvested), as well as tumor histologic subtype, were associated with cancer-specific survival in 66 stage II non-ampullary small bowel adenocarcinoma patients, collected through the Small Bowel Cancer Italian Consortium. A central histopathology review was performed. Mismatch repair deficiency was tested by immunohistochemistry for MLH1, MSH2, MSH6 and PMS2, and confirmed by polymerase chain reaction for microsatellite instability.Results. We identified mismatch repair deficiency, glandular/medullary histologic subtype, and celiac disease as significant predictors of favorable cancer-specific survival using univariable analysis with retained significance in bivariable models adjusted for pT stage. Among the high-risk features, only T4 showed a significant association with an increased risk of death; however, its prognostic value was not independent of mismatch repair status.Conclusions. Mismatch repair protein expression, histologic subtype, association with celiac disease, and, in the mismatch repair proficient subset only, T stage, may help identify patients who may benefit from adjuvant chemotherapy.[GRAPHICS].

Id prodotto:

115843

Handle IRIS:

11562/1023445

ultima modifica:

16 novembre 2022

Citazione bibliografica:

Vanoli, Alessandro; Grillo, Federica; Guerini, Camilla; Neri, Giuseppe; Arpa, Giovanni; Klersy, Catherine; Nesi, Gabriella; Giuffrida, Paolo; Sampietro, Gianluca; Ardizzone, Sandro; Fociani, Paolo; Fiocca, Roberto; Latella, Giovanni; Sessa, Fausto; D'Errico, Antonietta; Malvi, Deborah; Mescoli, Claudia; Rugge, Massimo; Ferrero, Stefano; Poggioli, Gilberto; Rizzello, Fernando; Macciomei, Maria C; Santini, Donatella; Volta, Umberto; De Giorgio, Roberto; Caio, Giacomo; Calabrò, Antonio; Ciacci, Carolina; D'Armiento, Maria; Rizzo, Aroldo; Solina, Gaspare; Martino, Michele; Tonelli, Francesco; Villanacci, Vincenzo; Cannizzaro, Renato; Canzonieri, Vincenzo; Florena, Ada Maria; Biancone, Livia; Monteleone, Giovanni; Caronna, Roberto; Ciardi, Antonio; Elli, Luca; Caprioli, Flavio; Vecchi, Maurizio; D'Incà, Renata; Zingone, Fabiana; D'Odorico, Anna; Lenti, Marco Vincenzo; Oreggia, Barbara; Reggiani Bonetti, Luca; Giannone, Antonino Giulio; Orlandi, Augusto; Barresi, Valeria; Ciccocioppo, Rachele; Amodeo, Giuseppe; Biletta, Elena; Luinetti, Ombretta; Pedrazzoli, Paolo; Pietrabissa, Andrea; Corazza, Gino Roberto; Solcia, Enrico; Paulli, Marco; Di Sabatino, Antonio, Prognostic Role of Mismatch Repair Status, Histotype and High-Risk Pathologic Features in Stage II Small Bowel Adenocarcinomas «ANNALS OF SURGICAL ONCOLOGY» , vol. 28 , n. 2 , 2021 , pp. 1167-1177

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo