Pubblicazioni

Autori:

Fadini, Gian Paolo; Sciannameo, Veronica; Franzetti, Ivano; Bottigliengo, Daniele; D'Angelo, Paola; Vinci, Carmela; Berchialla, Paola; Arena, Salvatore; Buzzetti, Raffaella; Avogaro, Angelo; Consoli, Agostino; Formoso, Gloria; Grossi, Giovanni; Pucci, Achiropita; Sesti, Giorgio; Andreozzi, Francesco; Capobianco, Giuseppe; Gatti, Adriano; Bonadonna, Riccardo; Zavaroni, Ivana; Dei Cas, Alessandra; Felace, Giuseppe; Li Volsi, Patrizia; Buzzetti, Raffaella; Leto, Gaetano; Sorice, Gian Pio; D'Angelo, Paola; Morano, Susanna; Bossi, Antonio Carlo; Duratorre, Edoardo; Franzetti, Ivano; Morpurgo, Paola Silvia; Orsi, Emanuela; Querci, Fabrizio; Boemi, Massimo; D'Angelo, Federica; Petrelli, Massimiliano; Aimaretti, Gianluca; Karamouzis, Ioannis; Cavalot, Franco; Saglietti, Giuseppe; Cazzetta, Giuliana; Cervone, Silvestre; Devangelio, Eleonora; Lamacchia, Olga; Arena, Salvatore; Di Benedetto, Antonino; Frittitta, Lucia; Giordano, Carla; Piro, Salvatore; Rizzo, Manfredi; Chianetta, Roberta; Mannina, Carlo; Anichini, Roberto; Penno, Giuseppe; Solini, Anna; Fattor, Bruno; Bonora, Enzo; Cigolini, Massimo; Lapolla, Annunziata; Chilelli, Nino Cristiano; Poli, Maurizio; Simioni, Natalino; Frison, Vera; Vinci, Carmela

Titolo:

Similar effectiveness of dapagliflozin and GLP-1 receptor agonists concerning combined endpoints in routine clinical practice: A multicentre retrospective study

Anno:

2019

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

DIABETES, OBESITY AND METABOLISM

ISSN Rivista:

1462-8902

N° Volume:

21

Numero o Fascicolo:

8

Intervallo pagine:

1886-1894

Parole chiave:

Exenatide; Female; Glucagon-Like Peptide-1 Receptor; Glucosides; Glycated Hemoglobin A; Humans; Hypoglycemic Agents; Liraglutide; Male; Middle Aged; Retrospective Studies; Treatment Outcome; GLP-1 analogue; antidiabetic drug; dapagliflozin; glycaemic control; observational study; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Therapy, Combination

Breve descrizione dei contenuti:

Aims According to cardiovascular outcome trials, some sodium-glucose contransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) are recommended for secondary cardiovascular prevention in type 2 diabetes (T2D). In this real-world study, we compared the simultaneous reductions in HbA1c, body weight and systolic blood pressure after initiation of dapagliflozin or GLP-1RA as second or a more advanced line of therapy. Materials and methods DARWIN-T2D was a retrospective multi-centre study conducted at diabetes specialist clinics in Italy that compared T2D patients who initiated dapagliflozin or GLP-1RA (exenatide once weekly or liraglutide). Data were collected at baseline and at the first follow-up visit after 3 to 12 months. The primary endpoint was the proportion of patients achieving a simultaneous reduction in HbA1c, body weight and systolic blood pressure. To reduce confounding, we used multivariable adjustment (MVA) or propensity score matching (PSM). Results Totals of 473 patients initiating dapagliflozin and 336 patients initiating GLP-1RA were included. The two groups differed in age, diabetes duration, HbA1c, weight and concomitant medications. The median follow-up was 6 months in both groups. Using MVA or PSM, the primary endpoint was observed in 30% to 32% of patients, with no difference between groups. Simultaneous reduction of HbA1c, BP and SBP by specific threshold, as well as achievement of final goals, did not differ between groups. GLP-1RA reduced HbA1c by 0.3% more than the reduction achieved with dapagliflozin. Conclusion In routine specialist care, initiation of dapagliflozin can be as effective as initiation of a GLP-1RA for attainment of combined risk factor goals.

Id prodotto:

117708

Handle IRIS:

11562/1030303

ultima modifica:

31 ottobre 2024

Citazione bibliografica:

Fadini, Gian Paolo; Sciannameo, Veronica; Franzetti, Ivano; Bottigliengo, Daniele; D'Angelo, Paola; Vinci, Carmela; Berchialla, Paola; Arena, Salvatore; Buzzetti, Raffaella; Avogaro, Angelo; Consoli, Agostino; Formoso, Gloria; Grossi, Giovanni; Pucci, Achiropita; Sesti, Giorgio; Andreozzi, Francesco; Capobianco, Giuseppe; Gatti, Adriano; Bonadonna, Riccardo; Zavaroni, Ivana; Dei Cas, Alessandra; Felace, Giuseppe; Li Volsi, Patrizia; Buzzetti, Raffaella; Leto, Gaetano; Sorice, Gian Pio; D'Angelo, Paola; Morano, Susanna; Bossi, Antonio Carlo; Duratorre, Edoardo; Franzetti, Ivano; Morpurgo, Paola Silvia; Orsi, Emanuela; Querci, Fabrizio; Boemi, Massimo; D'Angelo, Federica; Petrelli, Massimiliano; Aimaretti, Gianluca; Karamouzis, Ioannis; Cavalot, Franco; Saglietti, Giuseppe; Cazzetta, Giuliana; Cervone, Silvestre; Devangelio, Eleonora; Lamacchia, Olga; Arena, Salvatore; Di Benedetto, Antonino; Frittitta, Lucia; Giordano, Carla; Piro, Salvatore; Rizzo, Manfredi; Chianetta, Roberta; Mannina, Carlo; Anichini, Roberto; Penno, Giuseppe; Solini, Anna; Fattor, Bruno; Bonora, Enzo; Cigolini, Massimo; Lapolla, Annunziata; Chilelli, Nino Cristiano; Poli, Maurizio; Simioni, Natalino; Frison, Vera; Vinci, Carmela, Similar effectiveness of dapagliflozin and GLP-1 receptor agonists concerning combined endpoints in routine clinical practice: A multicentre retrospective study «DIABETES, OBESITY AND METABOLISM» , vol. 21 , n. 8 , 2019 , pp. 1886-1894

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo