Pubblicazioni

Autori:

Pengo, Martino F; Soranna, Davide; Giontella, Alice; Perger, Elisa; Mattaliano, Paola; Schwarz, Esther Irene; Lombardi, Carolina; Bilo, Grzegorz; Zambon, Antonella; Steier, Joerg; Parati, Gianfranco; Minuz, Pietro; Fava, Cristiano

Titolo:

Obstructive sleep apnoea treatment and blood pressure: which phenotypes predict a response? A systematic review and meta-analysis

Anno:

2020

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

European Respiratory Journal

ISSN Rivista:

0903-1936

N° Volume:

55

Numero o Fascicolo:

5

Intervallo pagine:

1901945-1901958

Parole chiave:

obstructive sleep apnea; meta-analysis; continuous positive airway pressure (CPAP)

Breve descrizione dei contenuti:

The treatment for obstructive sleep apnoea (OSA) with continuous positive airway pressure (CPAP) or mandibular advancement devices (MADs) is associated with blood pressure (BP) reduction; however, the overall effect is modest. The aim of this systematic review and meta-analysis of randomised controlled trials (RCTs) comparing the effect of such treatments on BP was to identify subgroups of patients who respond best to treatment.The article search was performed in three different databases with specific search terms and selection criteria. From 2289 articles, we included 68 RCTs that compared CPAP or MADs with either passive or active treatment. When all the studies were pooled together, CPAP and MADs were associated with a mean BP reduction of -2.09 (95% CI -2.78- -1.40) mmHg for systolic BP and -1.92 (95% CI -2.40- -1.43) mmHg for diastolic BP and -1.27 (95% CI -2.34- -0.20) mmHg for systolic BP and -1.11 (95% CI -1.82- -0.41) mmHg for diastolic BP, respectively. The subgroups of patients who showed a greater response were those aged <60 years (systolic BP -2.93 mmHg), with uncontrolled BP at baseline (systolic BP -4.14 mmHg) and with severe oxygen desaturations (minimum arterial oxygen saturation measured by pulse oximetry <77%) at baseline (24-h systolic BP -7.57 mmHg).Although this meta-analysis shows that the expected reduction of BP by CPAP/MADs is modest, it identifies specific characteristics that may predict a pronounced benefit from CPAP in terms of BP control. These findings should be interpreted with caution; however, they are particularly important in identifying potential phenotypes associated with BP reduction in patients treated for OSA.

Id prodotto:

118902

Handle IRIS:

11562/1034339

ultima modifica:

29 gennaio 2025

Citazione bibliografica:

Pengo, Martino F; Soranna, Davide; Giontella, Alice; Perger, Elisa; Mattaliano, Paola; Schwarz, Esther Irene; Lombardi, Carolina; Bilo, Grzegorz; Zambon, Antonella; Steier, Joerg; Parati, Gianfranco; Minuz, Pietro; Fava, Cristiano, Obstructive sleep apnoea treatment and blood pressure: which phenotypes predict a response? A systematic review and meta-analysis «European Respiratory Journal» , vol. 55 , n. 5 , 2020 , pp. 1901945-1901958

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo