Pubblicazioni

Autori:

Montaldo, Elisa; Lusito, Eleonora; Bianchessi, Valentina; Caronni, Nicoletta; Scala, Serena; Basso-Ricci, Luca; Cantaffa, Carla; Masserdotti, Alice; Barilaro, Mattia; Barresi, Simona; Genua, Marco; Maria Vittoria, Francesco; Barbiera, Giulia; Lazarevic, Dejan; Messina, Carlo; Xue, Elisabetta; Marktel, Sarah; Tresoldi, Cristina; Milani, Raffaella; Ronchi, Paola; Gattillo, Salvatore; Santoleri, Luca; Di Micco, Raffaella; Ditadi, Andrea; Belfiori, Giulio; Aleotti, Francesca; Maria Naldini, Matteo; Gentner, Bernhard; Gardiman, Elisa; Tamassia, Nicola; Cassatella, Marco Antonio; Hidalgo, Andr. s.; Kwok, Immanuel; Guan Ng, Lai; Crippa, Stefano; Falconi, Massimo; Pettinella, Francesca; Scapini, Patrizia; Naldini, Luigi; Ciceri, Fabio; Aiuti and Renato Ostuni, Alessandro

Titolo:

Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress

Anno:

2022

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

Sì

Nome rivista:

Nature Immunology

ISSN Rivista:

1529-2908

N° Volume:

23

Numero o Fascicolo:

10

Editore:

PNG

Intervallo pagine:

1470-1483

Parole chiave:

neutrophils,heterogeneity,inflammation

Breve descrizione dei contenuti:

Traditionally viewed as poorly plastic, neutrophils are now recognized as functionally diverse. However, the extent and determinants of neutrophil heterogeneity in humans remain unclear. We performed a comprehensive immunophenotypic and transcriptome analysis, at bulk and single-cell level, of neutrophils from healthy donors and patients undergoing stress myelopoiesis upon exposure to growth factors, transplantation of hematopoietic stem cells (HSC-T), development of pancreatic cancer, and viral infection. We uncover an extreme diversity of human neutrophils in vivo, reflecting the rates of cell mobilization, differentiation, and exposure to environmental signals. Integrated control of developmental and inducible transcriptional programs linked flexible granulopoietic outputs with elicitation of context-dependent functional responses. In this context, we detected an acute interferon (IFN) response in the blood of HSC-T patients that was mirrored by marked upregulation of IFN-stimulated genes in neutrophils but not in monocytes. Systematic characterization of human neutrophil plasticity may uncover clinically relevant biomarkers and support the development of diagnostic and therapeutic tools.

Id prodotto:

129319

Handle IRIS:

11562/1073429

ultima modifica:

23 febbraio 2023

Citazione bibliografica:

Montaldo, Elisa; Lusito, Eleonora; Bianchessi, Valentina; Caronni, Nicoletta; Scala, Serena; Basso-Ricci, Luca; Cantaffa, Carla; Masserdotti, Alice; Barilaro, Mattia; Barresi, Simona; Genua, Marco; Maria Vittoria, Francesco; Barbiera, Giulia; Lazarevic, Dejan; Messina, Carlo; Xue, Elisabetta; Marktel, Sarah; Tresoldi, Cristina; Milani, Raffaella; Ronchi, Paola; Gattillo, Salvatore; Santoleri, Luca; Di Micco, Raffaella; Ditadi, Andrea; Belfiori, Giulio; Aleotti, Francesca; Maria Naldini, Matteo; Gentner, Bernhard; Gardiman, Elisa; Tamassia, Nicola; Cassatella, Marco Antonio; Hidalgo, Andr. s.; Kwok, Immanuel; Guan Ng, Lai; Crippa, Stefano; Falconi, Massimo; Pettinella, Francesca; Scapini, Patrizia; Naldini, Luigi; Ciceri, Fabio; Aiuti and Renato Ostuni, Alessandro, Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress «Nature Immunology» , vol. 23 , n. 10 , 2022 , pp. 1470-1483

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