Pubblicazioni

Autori:

Recchiuti, Antonio; Federti, Enrica; Matte', Alessandro; Mazzi, Filippo; Ceolan, Jacopo; Porreca, Annamaria; Di Nicola, Marta; Menotti, Sofia; Alivernini, Stefano; DE FRANCESCHI, Lucia

Titolo:

Impaired pro‐resolving mechanisms promote abnormal NETosis , fueling autoimmunity in sickle cell disease

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

American Journal of Hematology

ISSN Rivista:

0361-8609

N° Volume:

98

Numero o Fascicolo:

3

Intervallo pagine:

E45-E48

Parole chiave:

neptosis, sickle cell disease, immunity

Breve descrizione dei contenuti:

Sickle cell disease (SCD) is a worldwide distributed hereditary red cell disorders with still high mortality and morbidity and limited therapeutic options. SCD is characterized by anemia, chronic hemolysis, and acute vaso-occlusive painful crises. The biocomplexity of SCD goes beyond red cells, involving neutrophils and soluble factors such as cytokines or alternative complement pathway intensively cross-talking with vascular endothelial cells. In addition, in SCD, the overactivation of neutrophils contributes to the production of neutrophil extracellular traps (NETs) (1, 2). This might trigger endothelial vascular injury, promoting acute sickle cell related events and increasing the risk of infections in patients with SCD

Id prodotto:

133163

Handle IRIS:

11562/1090250

ultima modifica:

30 ottobre 2024

Citazione bibliografica:

Recchiuti, Antonio; Federti, Enrica; Matte', Alessandro; Mazzi, Filippo; Ceolan, Jacopo; Porreca, Annamaria; Di Nicola, Marta; Menotti, Sofia; Alivernini, Stefano; DE FRANCESCHI, Lucia, Impaired pro‐resolving mechanisms promote abnormal NETosis , fueling autoimmunity in sickle cell disease «American Journal of Hematology» , vol. 98 , n. 3 , 2023 , pp. E45-E48

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