Pubblicazioni

Autori:

Toffali, Lara; D'Ulivo, Beatrice; Giagulli, Cinzia; Montresor, Alessio; Zenaro, Elena; Delledonne, Massimo; Rossato, Marzia; Iadarola, Barbara; Sbarbati, Andrea; Bernardi, Paolo; Angelini, Gabriele; Rossi, Barbara; Lopez, Nicola; Linke, Wolfgang A; Unger, Andreas; Di Silvestre, Dario; Benazzi, Louise; De Palma, Antonella; Motta, Sara; Constantin, Gabriela; Mauri, Pierluigi; Laudanna, Carlo

Titolo:

An isoform of the giant protein titin is a master regulator of human T lymphocyte trafficking

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

CELL REPORTS

ISSN Rivista:

2211-1247

N° Volume:

42

Numero o Fascicolo:

5

Intervallo pagine:

1-29

Parole chiave:

CP: Immunology; adhesion; cell deformability; chemokine; integrin activation; leukocyte trafficking; microvilli; migration; selectin; signal transduction; titin

Breve descrizione dei contenuti:

Response to multiple microenvironmental cues and resilience to mechanical stress are essential features of trafficking leukocytes. Here, we describe unexpected role of titin (TTN), the largest protein encoded by the human genome, in the regulation of mechanisms of lymphocyte trafficking. Human T and B lymphocytes express five TTN isoforms, exhibiting cell-specific expression, distinct localization to plasma membrane microdomains, and different distribution to cytosolic versus nuclear compartments. In T lymphocytes, the LTTN1 isoform governs the morphogenesis of plasma membrane microvilli independently of ERM protein phosphorylation status, thus allowing selectin-mediated capturing and rolling adhesions. Likewise, LTTN1 controls chemokine-triggered integrin activation. Accordingly, LTTN1 mediates rho and rap small GTPases activation, but not actin polymerization. In contrast, chemotaxis is facilitated by LTTN1 degradation. Finally, LTTN1 controls resilience to passive cell deformation and ensures T lymphocyte survival in the blood stream. LTTN1 is, thus, a critical and versatile housekeeping regulator of T lymphocyte trafficking.

Pagina Web:

https://doi.org/10.1016/j.celrep.2023.112516

Id prodotto:

133858

Handle IRIS:

11562/1094287

ultima modifica:

27 gennaio 2025

Citazione bibliografica:

Toffali, Lara; D'Ulivo, Beatrice; Giagulli, Cinzia; Montresor, Alessio; Zenaro, Elena; Delledonne, Massimo; Rossato, Marzia; Iadarola, Barbara; Sbarbati, Andrea; Bernardi, Paolo; Angelini, Gabriele; Rossi, Barbara; Lopez, Nicola; Linke, Wolfgang A; Unger, Andreas; Di Silvestre, Dario; Benazzi, Louise; De Palma, Antonella; Motta, Sara; Constantin, Gabriela; Mauri, Pierluigi; Laudanna, Carlo, An isoform of the giant protein titin is a master regulator of human T lymphocyte trafficking «CELL REPORTS» , vol. 42 , n. 5 , 2023 , pp. 1-29

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo