Pubblicazioni

Autori:

Fassio, Angelo; Atzeni, Fabiola; Rossini, Maurizio; D'Amico, Valeria; Cantatore, Francesco; Chimenti, Maria Sole; Crotti, Chiara; Frediani, Bruno; Giusti, Andrea; Peluso, Giusy; Rovera, Guido; Scolieri, Palma; Raimondo, Vincenzo; Gatti, Davide; On Behalf Of The Study Group On Osteoporosis And Skeletal Metabolic Diseases Of The Italian Society Of Rheumatology, Null

Titolo:

Osteoimmunology of Spondyloarthritis

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ISSN Rivista:

1422-0067

N° Volume:

24

Numero o Fascicolo:

19

Intervallo pagine:

1-5

Parole chiave:

osteoimmunology; pathophysiology; spondyloarthritis

Breve descrizione dei contenuti:

: The mechanisms underlying the development of bone damage in the context of spondyloarthritis (SpA) are not completely understood. To date, a considerable amount of evidence indicates that several developmental pathways are crucially involved in osteoimmunology. The present review explores the biological mechanisms underlying the relationship between inflammatory dysregulation, structural progression, and osteoporosis in this diverse family of conditions. We summarize the current knowledge of bone biology and balance and the foundations of bone regulation, including bone morphogenetic protein, the Wnt pathway, and Hedgehog signaling, as well as the role of cytokines in the development of bone damage in SpA. Other areas surveyed include the pathobiology of bone damage and systemic bone loss (osteoporosis) in SpA and the effects of pharmacological treatment on focal bone damage. Lastly, we present data relative to a survey of bone metabolic assessment in SpA from Italian bone specialist rheumatology centers. The results confirm that most of the attention to bone health is given to postmenopausal subjects and that the aspect of metabolic bone health may still be underrepresented. In our opinion, it may be the time for a call to action to increase the interest in and focus on the diagnosis and management of SpA.

Id prodotto:

136285

Handle IRIS:

11562/1114309

ultima modifica:

1 novembre 2024

Citazione bibliografica:

Fassio, Angelo; Atzeni, Fabiola; Rossini, Maurizio; D'Amico, Valeria; Cantatore, Francesco; Chimenti, Maria Sole; Crotti, Chiara; Frediani, Bruno; Giusti, Andrea; Peluso, Giusy; Rovera, Guido; Scolieri, Palma; Raimondo, Vincenzo; Gatti, Davide; On Behalf Of The Study Group On Osteoporosis And Skeletal Metabolic Diseases Of The Italian Society Of Rheumatology, Null, Osteoimmunology of Spondyloarthritis «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES» , vol. 24 , n. 19 , 2023 , pp. 1-5

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo