Pubblicazioni

Autori:

Carollo, Massimo; Crisafulli, Salvatore; Ciccimarra, Francesco; Andò, Giuseppe; Diemberger, Igor; Trifirò, Gianluca

Titolo:

Exploring the level of agreement among different drug-drug interaction checkers: a comparative study on direct oral anticoagulants

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY

ISSN Rivista:

1742-5255

N° Volume:

20

Numero o Fascicolo:

3

Intervallo pagine:

157-164

Parole chiave:

Direct-acting oral anticoagulants; drug-drug interactions; interaction checkers; summary of product characteristics

Breve descrizione dei contenuti:

Background: Direct oral anticoagulants (DOACs) may be involved in drug-drug interactions (DDIs) potentially increasing the risk of adverse drug reactions. This study aimed to evaluate the level of agreement among interaction checkers (ICs) and DOACs' summary of product characteristics (SPCs), in listing DDIs and in attributing DDIs' severity. Research design and methods: The level of agreement among five ICs (i.e. INTERCheck WEB, Micromedex, Lexicomp, Epocrates, and drugs.com) in identifying potential DDIs and in attributing severity categories was evaluated using Gwet's AC1 on all five ICs and by comparing groups of 4- and 2-pair sets of ICs. Results: A total of 486 potentially interacting drugs with dabigatran, 556 for apixaban, 444 for edoxaban, and 561 for rivaroxaban were reported. The level of agreement among the ICs in identifying potential DDIs was poor (range: 0.12-0.16). Similarly, it was low in 4 and 2-sets analyses. The level of agreement among the ICs in classifying the severity of potential DDIs was poor (range: 0.32-0.34), also in 4 and 2-sets analyses. Conclusions: The heterogeneity among different ICs and SPCs underscores the need to standardize DDIs datasets and to conduct real-world studies to generate evidence regarding the frequency and clinical relevance of potential DOACs-related DDIs.

Note:

Epub 2024 Feb 27

Id prodotto:

138060

Handle IRIS:

11562/1120066

ultima modifica:

24 maggio 2024

Citazione bibliografica:

Carollo, Massimo; Crisafulli, Salvatore; Ciccimarra, Francesco; Andò, Giuseppe; Diemberger, Igor; Trifirò, Gianluca, Exploring the level of agreement among different drug-drug interaction checkers: a comparative study on direct oral anticoagulants «EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY» , vol. 20 , n. 3 , 2024 , pp. 157-164

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