Pubblicazioni

Autori:

Mangiavillano, Benedetto; Facciorusso, Antonio; Di Matteo, Francesco Maria; Barbera, Carmelo; Larghi, Alberto; Rizzatti, Gianenrico; Carrara, Silvia; Lisotti, Andrea; Fusaroli, Pietro; De Luca, Luca; Di Leo, Milena; Conti Bellocchi, Maria Cristina; Spadaccini, Marco; Dabizzi, Emanuele; Auriemma, Francesco; Stigliano, Serena; Ramai, Daryl; Calabrese, Federica; Manfrin, Erminia; Paduano, Danilo; Hassan, Cesare; Repici, Alessandro; Crinó, Stefano Francesco

Titolo:

Establishing the optimal number of passes during EUS-FNB for diagnosis of pancreatic solid lesions: Prospective multicenter study

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

No

Nome rivista:

ENDOSCOPY INTERNATIONAL OPEN

ISSN Rivista:

2364-3722

N° Volume:

12

Numero o Fascicolo:

4

Intervallo pagine:

E467-E473

Parole chiave:

Endoscopic ultrasonography; Fine-needle aspiration/biopsy; Pancreas

Breve descrizione dei contenuti:

: Background and study aims The optimal number of needle passes during endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is not yet established. We aimed to perform a per-pass analysis of the diagnostic accuracy of EUS-FNB of solid pancreatic lesions using a 22G Franseen needle. Patients and methods Consecutive patients with solid pancreatic lesions referred to 11 Italian centers were prospectively enrolled. Three needle passes were performed; specimens were collected after each pass and processed individually as standard histology following macroscopic on-site evaluation (MOSE) by the endoscopist. The primary endpoint was diagnostic accuracy of each sequential pass. Final diagnosis was established based on surgical pathology or a clinical course of at least 6 months. Secondary endpoints were specimen adequacy, MOSE reliability, factors impacting diagnostic accuracy, and procedure-related adverse events. Results A total of 504 samples from 168 patients were evaluated. Diagnostic accuracy was 90.5% (85.0%-94.1%) after one pass and 97.6% (94.1%-99.3%) after two passes ( P =0.01). Similarly, diagnostic sensitivity and sample adequacy were significantly higher adding the second needle pass (90.2%, 84.6%-94.3% vs 97.5%, 93.8%-99.3%, P =0.009 and 91.1%, 85.7%-94.9% vs 98.2%, 95.8%-99.3%, P =0.009, one pass vs two passes, respectively). Accuracy, sensitivity, and adequacy remained the same after the third pass. The concordance between MOSE and histological evaluation was 89.9%. The number of passes was the only factor associated with accuracy. One case of mild acute pancreatitis (0.6%) was managed conservatively. Conclusions At least two passes should be performed for the diagnosis of solid pancreatic lesions. MOSE is a reliable tool to predict the histological adequacy of specimens.

Id prodotto:

138938

Handle IRIS:

11562/1124147

ultima modifica:

13 giugno 2024

Citazione bibliografica:

Mangiavillano, Benedetto; Facciorusso, Antonio; Di Matteo, Francesco Maria; Barbera, Carmelo; Larghi, Alberto; Rizzatti, Gianenrico; Carrara, Silvia; Lisotti, Andrea; Fusaroli, Pietro; De Luca, Luca; Di Leo, Milena; Conti Bellocchi, Maria Cristina; Spadaccini, Marco; Dabizzi, Emanuele; Auriemma, Francesco; Stigliano, Serena; Ramai, Daryl; Calabrese, Federica; Manfrin, Erminia; Paduano, Danilo; Hassan, Cesare; Repici, Alessandro; Crinó, Stefano Francesco, Establishing the optimal number of passes during EUS-FNB for diagnosis of pancreatic solid lesions: Prospective multicenter study «ENDOSCOPY INTERNATIONAL OPEN» , vol. 12 , n. 4 , 2024 , pp. E467-E473

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