Pubblicazioni

Autori:

Sposito, Marco; Eccher, Serena; Pasqualin, Luca; Scaglione, Ilaria Mariangela; Avancini, Alice; Tregnago, Daniela; Trestini, Ilaria; Insolda, Jessica; Bonato, Adele; Ugel, Stefano; Derosa, Lisa; Milella, Michele; Pilotto, Sara; Belluomini, Lorenzo

Titolo:

Characterizing the immune tumor microenvironment in ALK fusion-positive lung cancer: state-of-the-art and therapeutical implications

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

EXPERT REVIEW OF CLINICAL IMMUNOLOGY

ISSN Rivista:

1744-666X

N° Volume:

20

Numero o Fascicolo:

8

Intervallo pagine:

959-970

Parole chiave:

Anaplastic lymphoma kinase; Immunotherapy; Non-small cell lung cancer; Targeted therapy; Tumor immune microenvironment

Breve descrizione dei contenuti:

Introduction: Approximately 5% of non-small cell lung cancer (NSCLC), exhibits anaplastic lymphoma kinase (ALK) rearrangements. EML4-ALK fusions account for over 90% of ALK rearrangements in NSCLC. The advent of treatment targeting ALK has significantly improved survival rates in patients with advanced ALK-positive NSCLC. However, the emergence of resistance mechanisms and the subsequent progression disease inevitably occurs. The tumor immune microenvironment (TIME) plays a pivotal role in lung cancer, influencing disease development, patient's outcomes, and response to treatments. Areas covered: The aim of this review is to provide a comprehensive characterization of the TIME in ALK rearranged NSCLC and its intrinsic plasticity under treatment pressure. Expert opinion: Recognizing the fundamental role of the TIME in cancer progression has shifted the paradigm from a tumor cell-centric perspective to the understanding of a complex tumor ecosystem. Understanding the intricate dynamics of the TIME, its influence on treatment response, and the potential of immunotherapy in patients with ALK-positive NSCLC are currently among the primary research objectives in this patient population.

Pagina Web:

https://doi.org/10.1080/1744666X.2024.2372327

Id prodotto:

140380

Handle IRIS:

11562/1130109

ultima modifica:

26 gennaio 2025

Citazione bibliografica:

Sposito, Marco; Eccher, Serena; Pasqualin, Luca; Scaglione, Ilaria Mariangela; Avancini, Alice; Tregnago, Daniela; Trestini, Ilaria; Insolda, Jessica; Bonato, Adele; Ugel, Stefano; Derosa, Lisa; Milella, Michele; Pilotto, Sara; Belluomini, Lorenzo, Characterizing the immune tumor microenvironment in ALK fusion-positive lung cancer: state-of-the-art and therapeutical implications «EXPERT REVIEW OF CLINICAL IMMUNOLOGY» , vol. 20 , n. 8 , 2024 , pp. 959-970

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