Pubblicazioni

Autori:

Adami, Giovanni; Bixio, Riccardo; Virelli, Giulia; Galvagni, Isotta; Mastropaolo, Francesca; Morciano, Andrea; Ruzzon, Francesca; Messina, Valeria; Fracassi, Elena; Gatti, Davide; Viapiana, Ombretta; Carletto, Antonio; Rossini, Maurizio

Titolo:

Glucocorticoid sparing effect of Janus Kinase inhibitors compared to biological Disease Modifying Anti-Rheumatic Drugs in rheumatoid arthritis, a single-center retrospective analysis

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Rheumatology

ISSN Rivista:

1462-0324

Editore:

Oxford University Press

Intervallo pagine:

1-5

Parole chiave:

Baricitinib; Filgotinib; Glucocorticoid; JAKi; TNFi; Tofacitinib; Upadacitinib

Breve descrizione dei contenuti:

Background Glucocorticoid sparing in rheumatoid arthritis (RA) treatment is crucial to minimizing adverse effects associated with long-term use. Janus kinase inhibitors (JAKi) could potentially offer a more potent glucocorticoid-sparing effect than biologic DMARDs (bDMARDs)Material and methods This is a single-centre retrospective analysis of RA patients treated with JAKi or bDMARDs. Glucocorticoid tapering, rescue therapy and discontinuation were analysed through mixed-effects models, Poisson regression and multivariable logistic regression, respectively, adjusting for baseline disease activity, demographic factors and treatment line.Results A total of 716 RA patients treated with JAKi (n = 156) or bDMARDs (n = 560) were evaluated. JAKi treatment was associated with a more rapid reduction in glucocorticoid dose within the first 6 months and 60% higher odds of discontinuation compared with bDMARDs (adjusted odds ratio 1.63; 95% CI: 1.02, 2.60, P = 0.039). Despite a higher baseline glucocorticoid dose, over 50% of JAKi-treated patients discontinued glucocorticoids after 12 months, vs similar to 40% for bDMARDs. The need for glucocorticoid rescue therapy was significantly higher in the bDMARD group (rate ratio 2.66; 95% CI: 1.88, 3.74).Conclusion Our findings indicate that JAKi facilitate more rapid glucocorticoid tapering compared with bDMARDs in RA patients. These results underscore the potential of JAKi to reduce long-term glucocorticoid exposure, highlighting their value in RA management strategies, including minimizing glucocorticoid-related adverse effects.

Id prodotto:

143183

Handle IRIS:

11562/1146887

ultima modifica:

1 maggio 2025

Citazione bibliografica:

Adami, Giovanni; Bixio, Riccardo; Virelli, Giulia; Galvagni, Isotta; Mastropaolo, Francesca; Morciano, Andrea; Ruzzon, Francesca; Messina, Valeria; Fracassi, Elena; Gatti, Davide; Viapiana, Ombretta; Carletto, Antonio; Rossini, Maurizio, Glucocorticoid sparing effect of Janus Kinase inhibitors compared to biological Disease Modifying Anti-Rheumatic Drugs in rheumatoid arthritis, a single-center retrospective analysis «Rheumatology» , 2024 , pp. 1-5

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