Pubblicazioni

Autori:

Garancini, Mattia; Serenari, Matteo; Famularo, Simone; Cipriani, Federica; Ardito, Francesco; Russolillo, Nadia; Conci, Simone; Nicolini, Daniele; Perri, Pasquale; Zanello, Matteo; Iaria, Maurizio; Lai, Quirino; Romano, Maurizio; La Barba, Giuliano; Molfino, Sarah; Germani, Paola; Dominioni, Tommaso; Zimmiti, Giuseppe; Conticchio, Maria; Fumagalli, Luca; Zago, Mauro; Troci, Albert; Sciannamea, Ivano; Ferrari, Cecilia; Scotti, Mauro Alessandro; Griseri, Guido; Antonucci, Adelmo; Crespi, Michele; Pinotti, Enrico; Chiarelli, Marco; Memeo, Riccardo; Hilal, Mohamed Abu; Maestri, Marcello; Tarchi, Paola; Baiocchi, Gianluca; Ercolani, Giorgio; Zanus, Giacomo; Rossi, Massimo; Valle, Raffaele Dalla; Jovine, Elio; Frena, Antonio; Patauner, Stefan; Grazi, Gian Luca; Vivarelli, Marco; Ruzzenente, Andrea; Ferrero, Alessandro; Giuliante, Felice; Aldrighetti, Luca; Torzilli, Guido; Cescon, Matteo; Bernasconi, Davide; Romano, Fabrizio

Titolo:

Single large hepatocellular carcinoma > 5 cm with surgical indication: is it mandatory a major hepatectomy? a propensity-score weighted analysis

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

LANGENBECK'S ARCHIVES OF SURGERY

ISSN Rivista:

1435-2451

N° Volume:

409

Numero o Fascicolo:

1

Intervallo pagine:

1-12

Parole chiave:

Hepatocellular carcinoma; Large HCC; Major liver resection; Mortality; Overall survival

Breve descrizione dei contenuti:

Purpose Single large hepatocellular carcinoma >5cm (SLHCC) traditionally requires a major liver resection. Minor resections are often performed with the goal to reduce morbidity and mortality. Aim of the study was to establish if a major resection should be considered the best treatment for SLHCC or a more limited resection should be preferred. Methods A multicenter retrospective analysis of the HE.RC.O.LE.S. Group register was performed. All collected patients with surgically treated SLHCC were divided in 5 groups of treatment (major hepatectomy, sectorectomy, left lateral sectionectomy, segmentectomy, non-anatomical resection) and compared for baseline characteristics, short and long-term results. A propensity-score weighted analysis was performed. Results 535 patients were enrolled in the study. Major resection was associated with significantly increased major complications compared to left lateral sectionanectomy, segmentectomy and non-anatomical resection (all p<0.05) and borderline significant increased major complications compared to sectorectomy (p=0.08). Left lateral sectionectomy showed better overall survival compared to major resection (p=0.02), while other groups of treatment resulted similar to major hepatectomy group for the same item. Absence of oncological benefit after major resection and similar outcomes among the 5 groups of treatment was confirmed even in the sub-population excluding patients with macrovascular invasion. Conclusion Major resection was associated to increased major post-operative morbidity without long-term survival benefit; when technically feasible and oncologically adequate, minor resections should be preferred for the surgical treatment of SLHCC.

Id prodotto:

143778

Handle IRIS:

11562/1149762

ultima modifica:

17 aprile 2025

Citazione bibliografica:

Garancini, Mattia; Serenari, Matteo; Famularo, Simone; Cipriani, Federica; Ardito, Francesco; Russolillo, Nadia; Conci, Simone; Nicolini, Daniele; Perri, Pasquale; Zanello, Matteo; Iaria, Maurizio; Lai, Quirino; Romano, Maurizio; La Barba, Giuliano; Molfino, Sarah; Germani, Paola; Dominioni, Tommaso; Zimmiti, Giuseppe; Conticchio, Maria; Fumagalli, Luca; Zago, Mauro; Troci, Albert; Sciannamea, Ivano; Ferrari, Cecilia; Scotti, Mauro Alessandro; Griseri, Guido; Antonucci, Adelmo; Crespi, Michele; Pinotti, Enrico; Chiarelli, Marco; Memeo, Riccardo; Hilal, Mohamed Abu; Maestri, Marcello; Tarchi, Paola; Baiocchi, Gianluca; Ercolani, Giorgio; Zanus, Giacomo; Rossi, Massimo; Valle, Raffaele Dalla; Jovine, Elio; Frena, Antonio; Patauner, Stefan; Grazi, Gian Luca; Vivarelli, Marco; Ruzzenente, Andrea; Ferrero, Alessandro; Giuliante, Felice; Aldrighetti, Luca; Torzilli, Guido; Cescon, Matteo; Bernasconi, Davide; Romano, Fabrizio, Single large hepatocellular carcinoma > 5 cm with surgical indication: is it mandatory a major hepatectomy? a propensity-score weighted analysis «LANGENBECK'S ARCHIVES OF SURGERY» , vol. 409 , n. 1 , 2024 , pp. 1-12

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo