Pubblicazioni

Autori:

Cecchini, Sara; Di Rosa, Mirko; Fantechi, Lorenzo; Mecozzi, Sara; Matacchione, Giulia; Giuliani, Angelica; Monsurrò, Vladia; Zoppi, Lorenzo; Cardelli, Maurizio; Galeazzi, Roberta; Recchioni, Rina; Marchegiani, Francesca; Marra, Massimo; Sabbatinelli, Jacopo; Corsonello, Andrea; Sarzani, Riccardo; Cherubini, Antonio; Bonfigli, Anna Rita; Fornarelli, Daniela; Paci, Enrico; Procopio, Antonio Domenico; Olivieri, Fabiola; Bronte, Giuseppe

Titolo:

Relationship between imaging‐derived parameters and circulating microRNAs to study the degree of lung involvement in hospitalized geriatric patients with COVID‐19 pneumonia

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

GERIATRICS AND GERONTOLOGY INTERNATIONAL

ISSN Rivista:

1444-1586

N° Volume:

24

Numero o Fascicolo:

9

Intervallo pagine:

962-972

Parole chiave:

COVID‐19; computed tomography severity score; elderly; microRNA; pneumonia

Breve descrizione dei contenuti:

Aim: Chest computed tomography (CT) scan is useful to evaluate the type and extent of lung lesions in coronavirus disease 2019 (COVID-19) pneumonia. This study explored the association between radiological parameters and various circulating serum-derived markers, including microRNAs, in older patients with COVID-19 pneumonia. Methods: A retrospective analysis was designed to study geriatric patients (>= 75 years) with COVID-19 pneumonia, who underwent chest CT scan on admission, and for whom clinical data and serum samples were obtained. To quantify the extent of lung involvement, CT-score, the percentage of healthy lung (HL%), the percentage of ground glass opacity (GGO%), and the percentage of lung consolidation were assessed using computer-aided tools. The association of these parameters with two circulating microRNAs, miR-483-5p and miR-320b, previously identified as biomarkers of mortality risk in COVID-19 geriatric patients, was tested. Results: A total of 73 patients with COVID-19 pneumonia were evaluable (median age 85 years; interquartile range 82-90 years). Among chest CT-derived parameters, the percentage of lung consolidation (HR 1.08, 95% CI 1.02-1.14), CT-score (HR 1.14, 95% CI 1.03-1.25), and HL% (HR 0.97, 95% CI 0.95-0.99) emerged as significant predictors of mortality, whereas non-significant trends toward increased mortality were observed in patients with higher GGO%. We also found a significant positive association between serum miR-483-5p and GGO% (correlation coefficient 0.28; P = 0.018) and a negative association with HL% (correlation coefficient -0.27; P = 0.023). Conclusions: Overall, the extent of lung consolidation can be confirmed as a prognostic parameter of COVID-19 pneumonia in older patients. Among various serum-derived markers, miR-483-5p can help in exploring the degree of lung involvement, due to its association with higher GGO% and lower HL%.

Id prodotto:

144009

Handle IRIS:

11562/1151908

ultima modifica:

26 gennaio 2025

Citazione bibliografica:

Cecchini, Sara; Di Rosa, Mirko; Fantechi, Lorenzo; Mecozzi, Sara; Matacchione, Giulia; Giuliani, Angelica; Monsurrò, Vladia; Zoppi, Lorenzo; Cardelli, Maurizio; Galeazzi, Roberta; Recchioni, Rina; Marchegiani, Francesca; Marra, Massimo; Sabbatinelli, Jacopo; Corsonello, Andrea; Sarzani, Riccardo; Cherubini, Antonio; Bonfigli, Anna Rita; Fornarelli, Daniela; Paci, Enrico; Procopio, Antonio Domenico; Olivieri, Fabiola; Bronte, Giuseppe, Relationship between imaging‐derived parameters and circulating microRNAs to study the degree of lung involvement in hospitalized geriatric patients with COVID‐19 pneumonia «GERIATRICS AND GERONTOLOGY INTERNATIONAL» , vol. 24 , n. 9 , 2024 , pp. 962-972

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