Pubblicazioni

Autori:

Barei, Francesca; Calzari, Paolo; Pezzolo, Elena; Napolitano, Maddalena; Rossi, Mariateresa; Bruno Guanti, Mario; Caroppo, Francesca; Belloni Fortina, Anna; Patruno, Cataldo; Campanati, Anna; Bianchelli, Tommaso; Marco D’Agostino, Giovanni; Nettis, Eustachio; Pugliese, Francesco; di Vico, Francesca; Trave, Ilaria; Cozzani, Emanuele; Stingeni, Luca; Hansel, Katharina; Dall’Olio, Matilde; Grigolato, Laura; Coppola, Rosa; Panasiti, Vincenzo; Maurelli, Martina; Girolomoni, Giampiero; Ortoncelli, Michela; Ribero, Simone; Valerio Marzano, Angelo; Mariel Ferrucci, Silvia

Titolo:

Effectiveness of Tralokinumab Across Atopic Dermatitis Phenotypes

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

JOURNAL OF CLINICAL MEDICINE

ISSN Rivista:

2077-0383

Intervallo pagine:

1-12

Parole chiave:

atopic dermatitis; tralokinumab

Breve descrizione dei contenuti:

Tralokinumab, a fully human monoclonal antibody targeting IL-13, has shown efficacy and safety in clinical trials and real-life studies for atopic dermatitis (AD). However, data on its effectiveness across AD phenotypes are lim- ited. Methods: A multicentric study evaluated tralokinumab’s efficacy over 52 weeks in 416 severe AD patients. EASI (Eczema Area and Severity Index), P-NRS (Pruritus Numeri- cal Rating Scale), DLQI (Dermatology Life Quality Index), and ADCT (Atopic Dermatitis Control Tool) were recorded up to 52 weeks of treatment. Results: The EASI, P-NRS, DLQI, and ADCT trends across phenotypes showed significant improvement in all phenotype subgroups. By week 16, classical and generalized lichenoid phenotypes showed the highest EASI improvements compared to the generalized inflammatory (75.0 vs. 45.5 [p < 0.001] and 79.3 vs. 45.5 [p < 0.001]), with most achieving EASI-75 (p < 0.001, χ 2 = 25.96). By week 24, generalized lichenoid reached 100% EASI improvement, significantly outperforming other phenotypes. The highest EASI-75 rates were seen in classical, generalized lichenoid, and portrait/head and neck phenotypes (p = 0.016, χ 2 = 13.85). No significant differences were observed at weeks 32, 40, or 52. Conclusions: Our results suggest that tralokinumab’s durability and tolerability are consistent across the various phenotypes. The classical and generalized lichenoid were the fastest phenotypes to improve. However, given the uneven distribution of phenotypes and the gradual reduction in patient numbers over time, larger prospective studies are essential to confirm the observed trends.

Id prodotto:

144773

Handle IRIS:

11562/1157808

ultima modifica:

21 marzo 2025

Citazione bibliografica:

Barei, Francesca; Calzari, Paolo; Pezzolo, Elena; Napolitano, Maddalena; Rossi, Mariateresa; Bruno Guanti, Mario; Caroppo, Francesca; Belloni Fortina, Anna; Patruno, Cataldo; Campanati, Anna; Bianchelli, Tommaso; Marco D’Agostino, Giovanni; Nettis, Eustachio; Pugliese, Francesco; di Vico, Francesca; Trave, Ilaria; Cozzani, Emanuele; Stingeni, Luca; Hansel, Katharina; Dall’Olio, Matilde; Grigolato, Laura; Coppola, Rosa; Panasiti, Vincenzo; Maurelli, Martina; Girolomoni, Giampiero; Ortoncelli, Michela; Ribero, Simone; Valerio Marzano, Angelo; Mariel Ferrucci, Silvia, Effectiveness of Tralokinumab Across Atopic Dermatitis Phenotypes «JOURNAL OF CLINICAL MEDICINE» , 2025 , pp. 1-12

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo