Pubblicazioni

Autori:

Vergani, Michela; Borella, NICOLÒ DIEGO; Rizzo, Mariangela; Conti, Matteo; Perra, Silvia; Bianconi, Eleonora; Sani, Elena; Csermely, Alessandro; Grespan, Elisabetta; Targher, Giovanni; Perseghin, Gianluca; Mantovani, Alessandro; Ciardullo, Stefano

Titolo:

Metabolic dysfunction‐associated steatotic liver disease, insulin sensitivity and continuous glucose monitoring metrics in patients with type 1 diabetes: A multi‐centre cross‐sectional study

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

DIABETES, OBESITY AND METABOLISM

ISSN Rivista:

1462-8902

Intervallo pagine:

1-11

Parole chiave:

CAP; CMG; Fibroscan; MASLD; eGDR; estimated glucose disposal rate; hepatic steatosis; insulin resistance; metabolic dysfunction‐associated steatotic liver disease; type 1 diabetes

Breve descrizione dei contenuti:

Background and aim: We assessed the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and significant liver fibrosis in adults with type 1 diabetes mellitus (T1DM) and the association of MASLD with insulin sensitivity and continuous glucose monitoring metrics. Methods: We consecutively enrolled 198 adults with T1DM undergoing vibration-controlled transient elastography with liver stiffness measurement (LSM) and controlled attenuation parameter (CAP). All participants had a continuous glucose monitoring (CGM) device. Insulin sensitivity was evaluated by estimated glucose disposal rate (eGDR). MASLD was defined as CAP >= 248 db/m and the presence of at least one cardiometabolic risk factor. Significant liver fibrosis was defined as LSM >= 7 kPa. Results: Patients had a mean age of 56 years, mean BMI of 26.0 +/- 5.9 kg/m(2), and mean eGDR of 7.1 +/- 2.3 mg/kg/min. 73 (37%) patients had MASLD (using a CAP threshold of 274 dB/m), 16 (8.1%) of whom had significant liver fibrosis. MASLD was associated with a significantly lower eGDR (beta coefficient = -0.367, 95% confidence interval -0.472 to -0.261; p < 0.001). This association remained significant, even after adjustment for age, sex, body mass index, plasma triglycerides, diabetes duration, daily insulin dose, time above the range of glucose levels, LSM and chronic kidney disease. No association was observed between MASLD and CGM-derived metrics. These results were not different when we used a CAP threshold of 274 dB/m for diagnosing MASLD. Conclusion: In T1DM, MASLD was inversely associated with eGDR and biomarkers of insulin resistance but not with CGM-derived metrics.

Id prodotto:

145003

Handle IRIS:

11562/1159318

ultima modifica:

10 aprile 2025

Citazione bibliografica:

Vergani, Michela; Borella, NICOLÒ DIEGO; Rizzo, Mariangela; Conti, Matteo; Perra, Silvia; Bianconi, Eleonora; Sani, Elena; Csermely, Alessandro; Grespan, Elisabetta; Targher, Giovanni; Perseghin, Gianluca; Mantovani, Alessandro; Ciardullo, Stefano, Metabolic dysfunction‐associated steatotic liver disease, insulin sensitivity and continuous glucose monitoring metrics in patients with type 1 diabetes: A multi‐centre cross‐sectional study «DIABETES, OBESITY AND METABOLISM» , 2025 , pp. 1-11

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