Pubblicazioni

Autori:

Fassio, Angelo; Berti, Alvise; Mantovani, Alessandro; Adami, Giovanni; Pollastri, Francesco; Gatti, Davide; Bixio, Riccardo; Messina, Valeria; Rossini, Maurizio; Bertelle, Davide; Bertoldo, Eugenia; Galvagni, Isotta; Bortolotti, Roberto; Viapiana, Ombretta

Titolo:

Osteoporosis and fractures in systemic vasculitides: a systematic review and meta-analysis

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

FRONTIERS IN IMMUNOLOGY

ISSN Rivista:

1664-3224

N° Volume:

16

Intervallo pagine:

1-5

Parole chiave:

ANCA - associated vasculitis; DEXA - duel-energy X-ray absorptiometry; Takayasu ‘ s arteritis; fractures - bone; giant cell (temporal) arteritis; glucocorticoids; osteoporosis; vasculitis < rheumatic diseases

Breve descrizione dei contenuti:

Background/aim: We performed a systematic review and meta-analysis of observational studies aimed at investigating the prevalence of osteoporosis and osteoporotic fractures in subjects affected by systemic vasculitides (SVs) as well as to explore their risk of osteoporosis and osteoporotic fractures when compared to healthy controls. Methods: Scopus, Web of Science and PubMed were systematically searched from inception to February 2024 for observational studies investigating the prevalence of osteoporosis and fragility fractures in adults with SVs. In addition, when available, we assessed the odd ratios (OR) of prevalent osteoporosis and fragility fractures amongst subjects with SVs vs. healthy controls. Data from eligible studies were extracted, and meta-analysis was performed using a random effects model to obtain ORs with 95% confidence intervals (CIs). Subgroup analyses and meta-regressions were also performed. This study was registered in Open Science Framework (DOI: https://doi.org/10.17605/OSF.IO/3G7RJ). Results: Forty studies with 23,358 individuals affected by SVs were included. The overall prevalence of osteoporosis and fragility fractures in the SV patients were respectively 14.64% (95%CI 12.21-18.89), and 17.08% (95%CI 11.42-24.78). The ORs for osteoporosis and fragility fractures in SV patients when compared with healthy controls were 2.92 (95%CI 1.72-4.98) and 2.39 (95%CI 1.34-4.26) respectively. The univariable meta-regression analysis showed a significant association between cumulative glucocorticoids' dosage (total grams) and risk of prevalent osteoporosis (estimate = 0.0995, R2 = 0.24, p=0.0194). Conclusion: SVs are associated with an increased risk for osteoporosis and fragility fractures, suggesting that active vigilance and pre-emptive screening are recommended.

Id prodotto:

145494

Handle IRIS:

11562/1161272

ultima modifica:

7 maggio 2025

Citazione bibliografica:

Fassio, Angelo; Berti, Alvise; Mantovani, Alessandro; Adami, Giovanni; Pollastri, Francesco; Gatti, Davide; Bixio, Riccardo; Messina, Valeria; Rossini, Maurizio; Bertelle, Davide; Bertoldo, Eugenia; Galvagni, Isotta; Bortolotti, Roberto; Viapiana, Ombretta, Osteoporosis and fractures in systemic vasculitides: a systematic review and meta-analysis «FRONTIERS IN IMMUNOLOGY» , vol. 16 , 2025 , pp. 1-5

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo