Pubblicazioni

Autori:

Sota, Jurgen; Guerriero, Silvana; Lopalco, Giuseppe; Tufan, Abdurrahman; Ragab, Gaafar; Almaglouth, Ibrahim; Govoni, Marcello; Sfikakis, Petros P; Frassi, Micol; Vitale, Antonio; Kardas, Riza Can; Triggianese, Paola; Chimenti, Maria Sole; Aboabat, Aos A; Piga, Matteo; Monti, Sara; Sebastiani, Gian Domenico; Yildirim, Derya; Conforti, Alessandro; Gentileschi, Stefano; Dammacco, Rosanna; Hinojosa-Azaola, Andrea; Kawakami-Campos, Perla Ayumi; Ruffilli, Francesca; Torres-Ruiz, Jiram; Thabet, Maissa; Atig, Amira; Ruscitti, Piero; Cataldi, Giulia; Viapiana, Ombretta; Hatemi, Gülen; Karakoç, Alican; Costi, Stefania; Iagnocco, Annamaria; Crisafulli, Francesca; Fragoulis, George; Del Giudice, Emanuela; Hegazy, Mohamed Tharwat; Paroli, Maria Pia; Şahin, Ali; Morrone, Maria; Iannone, Florenzo; Opris-Belinski, Daniela; Asfina, Kazi Nur; Barone, Patrizia; Gaggiano, Carla; Kucuk, Hamit; Gicchino, Maria Francesca; Carubbi, Francesco; Caggiano, Valeria; Laskari, Katerina; Tharwat, Samar; Direskeneli, Haner; Alibaz-Oner, Fatma; Sevik, Gizem; Maier, Armin; Laymouna, Ahmed Hatem; Emmi, Giacomo; Akkoç, Nurullah; Tarsia, Maria; Sbalchiero, Jessica; Conti, Giovanni; Spinella, Rosaria; La Torre, Francesco; Tombetti, Enrico; Amin, Rana Hussein; Mauro, Angela; Karamanakos, Anastasios; Carreño, Ester; Fonollosa, Alex; Cattalini, Marco; Breda, Luciana; de-la-Torre, Alejandra; Wiesik-Szewczyk, Ewa; Cifuentes-González, Carlos; Ozen, Seza; Mazzei, Maria Antonietta; Tosi, Gian Marco; Frediani, Bruno; Balistreri, Alberto; Batu, Ezgi Deniz; Gupta, Vishali; Cantarini, Luca; Fabiani, Claudia

Titolo:

Impact of HLA-B51 on Uveitis and Retinal Vasculitis: Data from the AIDA International Network Registries on Ocular Inflammatory Disorders

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

OCULAR IMMUNOLOGY AND INFLAMMATION

ISSN Rivista:

0927-3948

N° Volume:

33

Numero o Fascicolo:

1

Intervallo pagine:

48-55

Parole chiave:

AIDA network uveitis registry; Behçet’s disease; HLA-B51; non-infectious uveitis; retinal vasculitis

Breve descrizione dei contenuti:

PurposeThe clinical relevance of human leukocyte antigen (HLA) subtypes such as HLA-B51 on Beh & ccedil;et's disease (BD)-related uveitis and non-infectious uveitis (NIU) unrelated to BD remains largely unknown.MethodsData were prospectively collected from the International AIDA Network Registry for BD and for NIU. We assessed differences between groups (NIU unrelated to BD and positive for HLA-B51, BD-related uveitis positive for HLA-B51 and BD-related uveitis negative for HLA-B51) in terms of long-term ocular complications, visual acuity (VA) measured by best corrected visual acuity (BCVA), anatomical pattern, occurrence of retinal vasculitis (RV) and macular edema over time.ResultsRecords of 213 patients (341 eyes) were analyzed. No differences in complications were observed (p = 0.465). With regard to VA, a significant difference was detected in median BCVA (p = 0.046), which was not maintained after Bonferroni correction (p = 0.060). RV was significantly more prevalent in NIU-affected patients who tested positive for HLA-B51, irrespective of the systemic diagnosis of BD (p = 0.025). No differences emerged in the occurrence of macular edema (p = 0.99).ConclusionsPatients with NIU testing positive for HLA-B51 exhibit an increased likelihood of RV throughout disease course, irrespective of a systemic diagnosis of BD. The rate of complications as well as VA are comparable between NIU cases unrelated to BD testing positive for HLA-B51 and uveitis associated with BD. Therefore, it is advisable to perform the HLA-B typing in patients with NIU or retinal vasculitis, even in the absence of typical BD features.

Id prodotto:

145535

Handle IRIS:

11562/1161360

ultima modifica:

8 maggio 2025

Citazione bibliografica:

Sota, Jurgen; Guerriero, Silvana; Lopalco, Giuseppe; Tufan, Abdurrahman; Ragab, Gaafar; Almaglouth, Ibrahim; Govoni, Marcello; Sfikakis, Petros P; Frassi, Micol; Vitale, Antonio; Kardas, Riza Can; Triggianese, Paola; Chimenti, Maria Sole; Aboabat, Aos A; Piga, Matteo; Monti, Sara; Sebastiani, Gian Domenico; Yildirim, Derya; Conforti, Alessandro; Gentileschi, Stefano; Dammacco, Rosanna; Hinojosa-Azaola, Andrea; Kawakami-Campos, Perla Ayumi; Ruffilli, Francesca; Torres-Ruiz, Jiram; Thabet, Maissa; Atig, Amira; Ruscitti, Piero; Cataldi, Giulia; Viapiana, Ombretta; Hatemi, Gülen; Karakoç, Alican; Costi, Stefania; Iagnocco, Annamaria; Crisafulli, Francesca; Fragoulis, George; Del Giudice, Emanuela; Hegazy, Mohamed Tharwat; Paroli, Maria Pia; Şahin, Ali; Morrone, Maria; Iannone, Florenzo; Opris-Belinski, Daniela; Asfina, Kazi Nur; Barone, Patrizia; Gaggiano, Carla; Kucuk, Hamit; Gicchino, Maria Francesca; Carubbi, Francesco; Caggiano, Valeria; Laskari, Katerina; Tharwat, Samar; Direskeneli, Haner; Alibaz-Oner, Fatma; Sevik, Gizem; Maier, Armin; Laymouna, Ahmed Hatem; Emmi, Giacomo; Akkoç, Nurullah; Tarsia, Maria; Sbalchiero, Jessica; Conti, Giovanni; Spinella, Rosaria; La Torre, Francesco; Tombetti, Enrico; Amin, Rana Hussein; Mauro, Angela; Karamanakos, Anastasios; Carreño, Ester; Fonollosa, Alex; Cattalini, Marco; Breda, Luciana; de-la-Torre, Alejandra; Wiesik-Szewczyk, Ewa; Cifuentes-González, Carlos; Ozen, Seza; Mazzei, Maria Antonietta; Tosi, Gian Marco; Frediani, Bruno; Balistreri, Alberto; Batu, Ezgi Deniz; Gupta, Vishali; Cantarini, Luca; Fabiani, Claudia, Impact of HLA-B51 on Uveitis and Retinal Vasculitis: Data from the AIDA International Network Registries on Ocular Inflammatory Disorders «OCULAR IMMUNOLOGY AND INFLAMMATION» , vol. 33 , n. 1 , 2025 , pp. 48-55

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo