Pubblicazioni

Autori:

D. Schena; G. C. Chieregato; M. De Gironcoli; D. Girelli; O. Olivieri; A. M. Stanzial; R. Corrocher; A. Bassi; S. Ferrari; P. Perazzoli; P. Guarini; A. Barba

Titolo:

Increased erythrocyte membrane arachidonate and platelet malondialdehyde (MDA) production in psoriasis: normalization after fish-oil

Anno:

1989

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Nazioni degli autori:

ITALIA

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Acta Dermato Venereologica. Supplementum

ISSN Rivista:

0365-8341

N° Volume:

146

Intervallo pagine:

42-44

Breve descrizione dei contenuti:

Evidence exists of platelet activation and increased thromboxane B2 production in psoriasis. In 13 patients suffering from psoriasis, we determined the lipid composition of erythrocyte membrane, erythrocyte and platelet glutathione peroxidase activity (E-GSH-Px; Plt-GSH-Px), platelet MDA production and bleeding time. Compared with normal controls, psoriatics showed a significant increase in erythrocyte membrane arachidonic acid (AA) (p less than 0.001) and polyunsaturated fatty acids (PUFA) (p less than 0.001), platelet MDA production (p less than 0.01) and E- and Plt-GSH-Px activity (p less than 0.01; p less than 0.01). After 8 weeks of fish-oil supplementation (20 ml/day) we observed the following changes: a) marked amelioration of skin lesions; b) normalization of membrane lipid pattern and platelet MDA production; c) a further increase in E- and Plt-GSH-Px activity (p less than 0.01; p less than 0.01); d) significant prolongation of bleeding time (p less than 0.05). Our data demonstrate: 1) a generalized perturbation of membrane lipid pattern in psoriasis, characterized by an excess of AA; 2) an activation of AA metabolism in platelets suggested by increased MDA production and GSH-Px activity; 3) dietary fish-oil may normalize membrane lipid pattern and reduce platelet hyperactivity in psoriasis.

Id prodotto:

2090

Handle IRIS:

11562/2090

depositato il:

20 luglio 2007

ultima modifica:

2 novembre 2016

Citazione bibliografica:

D. Schena; G. C. Chieregato; M. De Gironcoli; D. Girelli; O. Olivieri; A. M. Stanzial; R. Corrocher; A. Bassi; S. Ferrari; P. Perazzoli; P. Guarini; A. Barba, Increased erythrocyte membrane arachidonate and platelet malondialdehyde (MDA) production in psoriasis: normalization after fish-oil «Acta Dermato Venereologica. Supplementum» , vol. 146 , 1989 , pp. 42-44

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