Pubblicazioni

Autori:

D. Girelli; O. Olivieri; A. M. Stanzial; P. Guarini; M. T. Trevisan; A. Bassi; R. Corrocher

Titolo:

Factors affecting the thiobarbituric acid test as index of red blood cell susceptibility to lipid peroxidation: a multivariate analysis

Anno:

1994

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Nazioni degli autori:

ITALIA

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Clinica Chimica Acta

ISSN Rivista:

0009-8981

N° Volume:

227

Numero o Fascicolo:

1-2

Intervallo pagine:

45-57

Breve descrizione dei contenuti:

The relationship between formation of thiobarbituric acid reactive substances (TBARS) in red blood cells (RBC) after exposure to H2O2 and factors potentially able to modulate it was investigated by a multivariate analysis in 92 healthy volunteers. The independent covariates considered were: RBC membrane fatty acids and cholesterol, RBC antioxidant enzymes and zinc, plasma vitamins A and E and serum selenium, zinc and copper. The stepwise multiple-linear-regression analysis revealed RBC membrane fatty acids and cholesterol as predictors of a consistent proportion of the RBC-TBARS variability whereas none of the antioxidants entered the equation. The unsaturation index was the most important individual predictor; RBC-TBARS increased with increasing concentrations of total omega-3 polyunsaturated fatty acids, C 20:5 omega-3 and cholesterol, whereas they decreased with increasing concentrations of total monounsaturated fatty acids, saturated fatty acids, C 16:0 and C 18:0. It is suggested that formation of TBARS, at least in currently used conditions, reflects mainly the lipid composition of the tissue under investigation, without giving sufficient information about the status of the antioxidant defences.

Id prodotto:

2372

Handle IRIS:

11562/2372

depositato il:

20 luglio 2007

ultima modifica:

2 novembre 2016

Citazione bibliografica:

D. Girelli; O. Olivieri; A. M. Stanzial; P. Guarini; M. T. Trevisan; A. Bassi; R. Corrocher, Factors affecting the thiobarbituric acid test as index of red blood cell susceptibility to lipid peroxidation: a multivariate analysis «Clinica Chimica Acta» , vol. 227 , n. 1-2 , 1994 , pp. 45-57

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