Pubblicazioni

The effects on hTERT gene expression is an additional mechanism of amino-bisphosphonates in prostatic cancer cells.  (2008)

Autori:
Valenti MT; Dalle Carbonare L; Bertoldo F; Donatelli L; Lo Cascio V.
Titolo:
The effects on hTERT gene expression is an additional mechanism of amino-bisphosphonates in prostatic cancer cells.
Anno:
2008
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Nazioni degli autori:
ITALIA
Lingua:
Inglese
Formato:
A Stampa
Referee:
Nome rivista:
European Journal of Pharmacology
ISSN Rivista:
0014-2999
N° Volume:
580
Numero o Fascicolo:
1-2
Intervallo pagine:
36-42
Parole chiave:
hTERT expression, amino-bisphosphonate, Prostate Cancer
Breve descrizione dei contenuti:
interference with themevalonate pathway. In addition, it is well known that gene expression of hTERT, the catalytic subunit of the telomerase, is elevated in prostatic cancer. In the prostate cancer cell lines we investigated the effects on hTERT gene expression of several bisphosphonates.We also evaluated whether the observed levels of expression were affected by the exposure to an analogue of the geranylgeranylpyrophosphate, the geranylgeraniol used to recover the mevalonate pathway. Our results showed that the amino-bisphosphonates down-regulate hTERT gene expression and that combined treatment with geranylgeraniol and zoledronate was able to revert only partially the effects on viability; on the contrary, hTERT gene down-regulation was not affected by the restoration of the mevalonate pathway. These results support the hypothesis that prostatic cancer cells are targeted by aminobisphosphonates also through a different mechanism from the mevalonate pathway.
Id prodotto:
40822
Handle IRIS:
11562/316931
depositato il:
26 maggio 2008
ultima modifica:
2 novembre 2016
Citazione bibliografica:
Valenti MT; Dalle Carbonare L; Bertoldo F; Donatelli L; Lo Cascio V., The effects on hTERT gene expression is an additional mechanism of amino-bisphosphonates in prostatic cancer cells. «European Journal of Pharmacology» , vol. 580 , n. 1-22008pp. 36-42

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

Progetti Collegati
Titolo Dipartimento Responsabili
<<indietro

Attività

Strutture