Pubblicazioni

Autori:

Valenti, Maria Teresa; DALLE CARBONARE, Luca Giuseppe; Bertoldo, Francesco; Donatelli, Luca; LO CASCIO, Vincenzo

Titolo:

The effects on hTERT gene expression is an additional mechanism of amino-bisphosphonates in prostatic cancer cells

Anno:

2008

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

European Journal of Pharmacology

ISSN Rivista:

0014-2999

N° Volume:

580

Numero o Fascicolo:

1-2

Intervallo pagine:

36-42

Parole chiave:

hTERT expression; amino-bisphosphonate; Prostate Cancer

Breve descrizione dei contenuti:

interference with themevalonate pathway. In addition, it is well known that gene expression of hTERT, the catalytic subunit of the telomerase, is elevated in prostatic cancer. In the prostate cancer cell lines we investigated the effects on hTERT gene expression of several bisphosphonates.We also evaluated whether the observed levels of expression were affected by the exposure to an analogue of the geranylgeranylpyrophosphate, the geranylgeraniol used to recover the mevalonate pathway. Our results showed that the amino-bisphosphonates down-regulate hTERT gene expression and that combined treatment with geranylgeraniol and zoledronate was able to revert only partially the effects on viability; on the contrary, hTERT gene down-regulation was not affected by the restoration of the mevalonate pathway. These results support the hypothesis that prostatic cancer cells are targeted by aminobisphosphonates also through a different mechanism from the mevalonate pathway.

Id prodotto:

40822

Handle IRIS:

11562/316931

depositato il:

26 maggio 2008

ultima modifica:

2 dicembre 2022

Citazione bibliografica:

Valenti, Maria Teresa; DALLE CARBONARE, Luca Giuseppe; Bertoldo, Francesco; Donatelli, Luca; LO CASCIO, Vincenzo, The effects on hTERT gene expression is an additional mechanism of amino-bisphosphonates in prostatic cancer cells «European Journal of Pharmacology» , vol. 580 , n. 1-2 , 2008 , pp. 36-42

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