Pubblicazioni

Autori:

Scapini, Patrizia; Hu, Y; Chu, Cl; Migone, Ts; Defranco, Al; Cassatella, Marco Antonio; Lowell, Ca

Titolo:

Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice

Anno:

2010

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Journal of Experimental Medicine

ISSN Rivista:

0022-1007

N° Volume:

207

Numero o Fascicolo:

8

Intervallo pagine:

1757-1773

Parole chiave:

Autoimmunity; BAFF; IFN-{gamma}; Lyn-deficient mice

Breve descrizione dei contenuti:

Autoimmunity is traditionally attributed to altered lymphoid cell selection and/or tolerance, whereas the contribution of innate immune cells is less well understood. Autoimmunity is also associated with increased levels of B cell-activating factor of the TNF family (BAFF; also known as B lymphocyte stimulator), a cytokine that promotes survival of self-reactive B cell clones. We describe an important role for myeloid cells in autoimmune disease progression. Using Lyn-deficient mice, we show that overproduction of BAFF by hyperactive myeloid cells contributes to inflammation and autoimmunity in part by acting directly on T cells to induce the release of IFN-gamma. Genetic deletion of IFN-gamma or reduction of BAFF activity, achieved by either reducing myeloid cell hyperproduction or by treating with an anti-BAFF monoclonal antibody, reduced disease development in lyn(-/-) mice. The increased production of IFN-gamma in lyn(-/-) mice feeds back on the myeloid cells to further stimulate BAFF release. Expression of BAFF receptor on T cells was required for their full activation and IFN-gamma release. Overall, our data suggest that the reciprocal production of BAFF and IFN-gamma establishes an inflammatory loop between myeloid cells and T cells that exacerbates autoimmunity in this model. Our findings uncover an important pathological role of BAFF in autoimmune disorders.

Id prodotto:

57241

Handle IRIS:

11562/344319

depositato il:

21 febbraio 2014

ultima modifica:

11 novembre 2022

Citazione bibliografica:

Scapini, Patrizia; Hu, Y; Chu, Cl; Migone, Ts; Defranco, Al; Cassatella, Marco Antonio; Lowell, Ca, Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice «Journal of Experimental Medicine» , vol. 207 , n. 8 , 2010 , pp. 1757-1773

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