Pubblicazioni

Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte-endothelial interactions  (2011)

Autori:
Rossi, Barbara; Angiari, Stefano; Zenaro, Elena; Budui, Simona Luciana; Constantin, Gabriela
Titolo:
Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte-endothelial interactions
Anno:
2011
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Formato:
Elettronico
Referee:
Nome rivista:
Journal of Leukocyte Biology
ISSN Rivista:
0741-5400
N° Volume:
89
Intervallo pagine:
1-18
Parole chiave:
Vascular Inflammation; Central Nervous System Diseases; Leukocyte-endothelial Interactions
Breve descrizione dei contenuti:
Leukocyte trafficking from the blood into the tissues represents a key process during inflammation and requires multiple steps mediated by adhesion molecules and chemoattractants. Inflammation has a detrimental role in several diseases, and in such cases, the molecular mechanisms controlling leukocyte migration are potential therapeutic targets. Over the past 20 years, leukocyte migration in the CNS has been investigated almost exclusively in the context of stroke and MS. Experimental models of ischemic stroke have led to the characterization of adhesion molecules controlling leukocyte migration during acute inflammation, whereas EAE, the animal model of MS, has provided similar data for chronic inflammation. Such experiments have led to clinical trials of antileukocyte adhesion therapy, with consistently positive outcomes in human subjects with MS, showing that interference with leukocyte adhesion can ameliorate chronic inflammatory CNS diseases. This review summarizes our current understanding of the roles of adhesion molecules controlling leukocyte-endothelial interactions in stroke and MS, focusing on recently discovered, novel migration mechanisms. We also discuss the growing evidence suggesting a role for vascular inflammation and leukocyte trafficking in neurodegenerative diseases such as AD. Moreover, we highlight recent findings suggesting a role for leukocyte-endothelial interactions in the pathogenesis of seizures and epilepsy, thus linking endothelial activation and leukocyte trafficking to neuronal electrical hyperactivity. These emerging roles for leukocytes and leukocyte adhesion mechanisms in CNS diseases provide insight into the mechanisms of brain damage and may contribute to the development of novel therapeutic strategies.
Id prodotto:
58601
Handle IRIS:
11562/347180
depositato il:
23 dicembre 2010
ultima modifica:
3 agosto 2022
Citazione bibliografica:
Rossi, Barbara; Angiari, Stefano; Zenaro, Elena; Budui, Simona Luciana; Constantin, Gabriela, Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte-endothelial interactions «Journal of Leukocyte Biology» , vol. 892011pp. 1-18

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