Pubblicazioni

Microarray analysis on human neuroblastoma cells exposed to aluminum, ²(1-42)-amyloid or the ²(1-42)-amyloid aluminum complex.  (2011)

Autori:
Gatta V; Drago D; Fincati K; Valenti MT; Dalle Carbonare L; Sensi SL; Zatta P.
Titolo:
Microarray analysis on human neuroblastoma cells exposed to aluminum, ²(1-42)-amyloid or the ²(1-42)-amyloid aluminum complex.
Anno:
2011
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Nazioni degli autori:
ITALIA
Lingua:
Inglese
Formato:
Elettronico
Referee:
Nome rivista:
PLoS ONE
ISSN Rivista:
1932-6203
N° Volume:
6
Numero o Fascicolo:
1
Intervallo pagine:
1-16
Codice PMID:
21298039
Parole chiave:
amyloid, neuroblastoma, microarray
Breve descrizione dei contenuti:
Background: A typical pathological feature of Alzheimer's disease (AD) is the appearance in the brain of senile plaques made up of b-amyloid (Ab) and neurofibrillary tangles. AD is also associated with an abnormal accumulation of some metal ions, and we have recently shown that one of these, aluminum (Al), plays a relevant role in affecting Ab aggregation and neurotoxicity. Methodology: In this study, employing a microarray analysis of 35,129 genes, we investigated the effects induced by the exposure to the Ab142-Al (Ab-Al) complex on the gene expression profile of the neuronal-like cell line, SH-SY5Y. Principal Findings: The microarray assay indicated that, compared to Ab or Al alone, exposure to Ab-Al complex produced selective changes in gene expression. Some of the genes selectively over or underexpressed are directly related to AD. A further evaluation performed with Ingenuity Pathway analysis revealed that these genes are nodes of networks and pathways that are involved in the modulation of Ca2+ homeostasis as well as in the regulation of glutamatergic transmission and synaptic plasticity. Conclusions and Significance: Ab-Al appears to be largely involved in the molecular machinery that regulates neuronal as well as synaptic dysfunction and loss. Ab-Al seems critical in modulating key AD-related pathways such as glutamatergic transmission, Ca2+ homeostasis, oxidative stress, inflammation, and neuronal apoptosis.
Id prodotto:
61871
Handle IRIS:
11562/362911
depositato il:
21 febbraio 2016
ultima modifica:
2 novembre 2016
Allegati:
1
Citazione bibliografica:
Gatta V; Drago D; Fincati K; Valenti MT; Dalle Carbonare L; Sensi SL; Zatta P., Microarray analysis on human neuroblastoma cells exposed to aluminum, ²(1-42)-amyloid or the ²(1-42)-amyloid aluminum complex. «PLoS ONE» , vol. 6 , n. 12011pp. 1-16

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

Progetti Collegati
Titolo Dipartimento Responsabili
STUDIO DI ESPRESSIONE GENICA NELLA PATOLOGIA NEURODEGENERATIVA DI ALZHEIMER Dipartimento Medicina Luca Giuseppe Dalle Carbonare
<<indietro

Attività

Strutture