Pubblicazioni

Autori:

Scapini, Patrizia; Lamagna, C; Hu, Y; Lee, K; Tang, Q; Defranco, Al; Lowell, Ca

Titolo:

B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice

Anno:

2011

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

Sì

Nome rivista:

Proceedings of the National Academy of Sciences of the United States of America

ISSN Rivista:

0027-8424

N° Volume:

108

Numero o Fascicolo:

41

Intervallo pagine:

E823-E832

Parole chiave:

Lyn kinase deficient mice; autoimmune/autoinflammatory disease; B cells

Breve descrizione dei contenuti:

Lyn kinase deficient mice represent a well established genetic model of autoimmune/autoinflammatory disease that resembles systemic lupus erythematosus. We report that IL-10 plays a crucial immunosuppressive role in this model, modulating the inflammatory component of the disease caused by myeloid and T-cell activation. Double-mutant lyn(-/-)IL-10(-/-) mice manifested severe splenomegaly and lymphadenopathy, dramatically increased proinflammatory cytokine production, and severe tissue inflammation. Single-mutant lyn(-/-)mice showed expansion of IL-10-producing B cells. Interestingly, WT B cells adoptively transferred into lyn(-/-) mice showed increased differentiation into IL-10-producing B cells that assumed a similar phenotype to endogenous lyn(-/-) IL-10-producing B cells, suggesting that the inflammatory environment present in lyn(-/-) mice induces IL-10-producing B-cell differentiation. B cells, but not T or myeloid cells, were the critical source of IL-10 able to reduce inflammation and autoimmunity in double mutant lyn(-/-)IL-10(-/-) mice. IL-10 secretion by B cells was also crucial to sustain transcription factor Forkhead Box P3 (Foxp3) expression in regulatory T cells during disease development. These data reveal a dominant immunosuppressive function of B-cell-derived IL-10 in the Lyn-deficient model of autoimmunity, extending our current understanding of the role of IL-10 and IL-10-producing B cells in systemic lupus erythematosus.

Id prodotto:

62840

Handle IRIS:

11562/363841

depositato il:

21 febbraio 2014

ultima modifica:

27 novembre 2022

Citazione bibliografica:

Scapini, Patrizia; Lamagna, C; Hu, Y; Lee, K; Tang, Q; Defranco, Al; Lowell, Ca, B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice «Proceedings of the National Academy of Sciences of the United States of America» , vol. 108 , n. 41 , 2011 , pp. E823-E832

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