Pubblicazioni

NF-κB as a target for pancreatic cancer therapy.  (2012)

Autori:
Carbone, C.; Melisi, Davide
Titolo:
NF-κB as a target for pancreatic cancer therapy.
Anno:
2012
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Referee:
No
Nome rivista:
EXPERT OPINION ON THERAPEUTIC TARGETS
ISSN Rivista:
1472-8222
Intervallo pagine:
1-10
Parole chiave:
NFkB; TAK1
Breve descrizione dei contenuti:
Introduction: Pancreatic cancer is the fourth leading cause of adult cancer mortality in the USA. It represents one of the greatest challenges in cancer treatment. The NF-κB transcriptional factors are constitutively activated in the majority of pancreatic cancers and are involved in the regulation of numerous aspects of tumor development and progression. NF-κB and the signaling cascades that regulate its activity have thus become attractive targets for novel therapeutic approaches for pancreatic cancer. Areas covered: This review describes and discusses the most important advances in the comprehension of the complex molecular biology of NF-κB, as well as the development of novel NF-κB-targeting strategies for the treatment of pancreatic cancer. Expert opinion: Although the inhibition of NF-κB, especially when combined with more classic chemotherapeutic drugs, could be a promising therapeutic strategy, direct targeting NF-κB still faces important challenges. In the future, targeting nonredundant cytosolic mediators of the activation of NF-κB - such as TNF receptor associated factor family member-associated NF-κB activator -binding kinase 1 (TBK1) and TGF-beta activated kinase 1 (TAK1) - could represent a better approach to inhibit key processes in pancreatic tumor cells and make a difference for this devastating disease.
Pagina Web:
http://dx.doi.org/10.1517/14728222.2011.645806
Id prodotto:
66728
Handle IRIS:
11562/393944
depositato il:
27 marzo 2012
ultima modifica:
15 novembre 2022
Citazione bibliografica:
Carbone, C.; Melisi, Davide, NF-κB as a target for pancreatic cancer therapy. «EXPERT OPINION ON THERAPEUTIC TARGETS»2012pp. 1-10

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

Progetti Collegati
Titolo Dipartimento Responsabili
Mechanisms of resistance to chemoterapeutic and antiangiogenic drugs as novel targets for pancreatic cancer therapy Dipartimento Medicina Davide Melisi
<<indietro

Attività

Strutture

Condividi