Pubblicazioni

NF-ºB as a target for pancreatic cancer therapy.  (2012)

Autori:
C. Carbone;D. Melisi
Titolo:
NF-ºB as a target for pancreatic cancer therapy.
Anno:
2012
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Formato:
A Stampa
Referee:
No
Nome rivista:
EXPERT OPINION ON THERAPEUTIC TARGETS
ISSN Rivista:
1472-8222
Intervallo pagine:
1-10
Codice PMID:
22443181
Parole chiave:
NFkB, TAK1
Breve descrizione dei contenuti:
Introduction: Pancreatic cancer is the fourth leading cause of adult cancer mortality in the USA. It represents one of the greatest challenges in cancer treatment. The NF-ºB transcriptional factors are constitutively activated in the majority of pancreatic cancers and are involved in the regulation of numerous aspects of tumor development and progression. NF-ºB and the signaling cascades that regulate its activity have thus become attractive targets for novel therapeutic approaches for pancreatic cancer. Areas covered: This review describes and discusses the most important advances in the comprehension of the complex molecular biology of NF-ºB, as well as the development of novel NF-ºB-targeting strategies for the treatment of pancreatic cancer. Expert opinion: Although the inhibition of NF-ºB, especially when combined with more classic chemotherapeutic drugs, could be a promising therapeutic strategy, direct targeting NF-ºB still faces important challenges. In the future, targeting nonredundant cytosolic mediators of the activation of NF-ºB - such as TNF receptor associated factor family member-associated NF-ºB activator -binding kinase 1 (TBK1) and TGF-beta activated kinase 1 (TAK1) - could represent a better approach to inhibit key processes in pancreatic tumor cells and make a difference for this devastating disease.
Pagina Web:
http://dx.doi.org/10.1517/14728222.2011.645806
Id prodotto:
66728
Handle IRIS:
11562/393944
depositato il:
27 marzo 2012
ultima modifica:
2 novembre 2016
Citazione bibliografica:
C. Carbone;D. Melisi, NF-ºB as a target for pancreatic cancer therapy. «EXPERT OPINION ON THERAPEUTIC TARGETS»2012pp. 1-10

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Titolo Dipartimento Responsabili
Mechanisms of resistance to chemoterapeutic and antiangiogenic drugs as novel targets for pancreatic cancer therapy Dipartimento Medicina Davide Melisi
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