- Autori:
-
Angiari S;Donnarumma T;Rossi B;Dusi, S.;Pietronigro E;Zenaro E;Della Bianca V;Toffali L;Piacentino G;Budui S;Rennert P;Xiao S;Laudanna C;Casasnovas JM;Kuchroo VK;Constantin G
- Titolo:
-
TIM-1 Glycoprotein Binds the Adhesion Receptor P-Selectin and Mediates T Cell Trafficking during Inflammation and Autoimmunity
- Anno:
-
2014
- Tipologia prodotto:
-
Articolo in Rivista
- Tipologia ANVUR:
- Articolo su rivista
- Lingua:
-
Inglese
- Referee:
-
Sì
- Nome rivista:
- Immunity
- ISSN Rivista:
- 1074-7613
- N° Volume:
-
40
- Numero o Fascicolo:
-
4
- Intervallo pagine:
-
542-553
- Parole chiave:
-
autoimmune disease; leukocyte trafficking; Selectins; T cell immunoglobulin; mucin domain 1 (TIM-1)
- Breve descrizione dei contenuti:
- Selectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rolling of T helper 1 (Th1) and Th17, but not Th2 and regulatory T cells on P-selectin. Th1 and Th17 cells lacking the TIM-1 mucin domain showed reduced rolling in thrombin-activated mesenteric venules and inflamed brain microcirculation. Inhibition of TIM-1 had no effect on naive T cell homing, but it reduced T cell recruitment in a skin hypersensitivity model and blocked experimental autoimmune encephalomyelitis. Uniquely, the TIM-1 immunoglobulin variable domain was also required for P-selectin binding. Our data demonstrate that TIM-1 is a major P-selectin ligand with a specialized role in T cell trafficking during inflammatory responses and the induction of autoimmune disease.
- Note:
- pii: S1074-7613(14)00084-3
- Id prodotto:
-
80461
- Handle IRIS:
-
11562/703361
- depositato il:
-
17 luglio 2014
- ultima modifica:
-
12 novembre 2021
- Citazione bibliografica:
-
Angiari S;Donnarumma T;Rossi B;Dusi, S.;Pietronigro E;Zenaro E;Della Bianca V;Toffali L;Piacentino G;Budui S;Rennert P;Xiao S;Laudanna C;Casasnovas JM;Kuchroo VK;Constantin G,
TIM-1 Glycoprotein Binds the Adhesion Receptor P-Selectin and Mediates T Cell Trafficking during Inflammation and Autoimmunity
«Immunity»
, vol.
40
, n.
4
,
2014
,
pp. 542-553
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