Pubblicazioni

Social networking of human neutrophils within the immune system  (2014)

Autori:
Scapini P;Cassatella MA
Titolo:
Social networking of human neutrophils within the immune system
Anno:
2014
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Referee:
Nome rivista:
Blood
ISSN Rivista:
0006-4971
N° Volume:
124
Numero o Fascicolo:
5
Editore:
American Society of Hematology
Intervallo pagine:
710-719
Parole chiave:
neutrophils; neutrophil biology; neutrophil heterogeneity; neutrophil plasticity
Breve descrizione dei contenuti:
It is now widely recognized that neutrophils are highly versatile and sophisticated cells that display de novo synthetic capacity and may greatly extend their lifespan. In addition, concepts such as "neutrophil heterogeneity" and "neutrophil plasticity" have started to emerge, implying that, under pathological conditions, neutrophils may differentiate into discrete subsets defined by distinct phenotypic and functional profiles. A number of studies have shown that neutrophils act as effectors in both innate and adaptive immunoregulatory networks. In fact, once recruited into inflamed tissues, neutrophils engage into complex bidirectional interactions with macrophages, natural killer, dendritic and mesenchymal stem cells, B and T lymphocytes or platelets. As a result of this crosstalk, mediated either by contact-dependent mechanisms or cell-derived soluble factors, neutrophils and target cells reciprocally modulate their survival and activation status. Altogether, these novel aspects of neutrophil biology have shed a new light not only on the potential complex roles that neutrophils play during inflammation and immune responses, but also in the pathogenesis of several inflammatory disorders including infection, autoimmunity and cancer.
Note:
pii: blood-2014-03-453217
Id prodotto:
82143
Handle IRIS:
11562/750165
depositato il:
29 agosto 2014
ultima modifica:
12 novembre 2021
Citazione bibliografica:
Scapini P;Cassatella MA, Social networking of human neutrophils within the immune system «Blood» , vol. 124 , n. 52014pp. 710-719

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

Progetti Collegati
Titolo Dipartimento Responsabili
<<indietro

Attività

Strutture