GNAS Mutations: Drivers or Co-Pilots? Yet, Promising Diagnostic Biomarkers
Anno:
2016
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Formato:
A Stampa
Referee:
No
Nome rivista:
trends in cancer
ISSN Rivista:
2405-8033
N° Volume:
2
Numero o Fascicolo:
6
Intervallo pagine:
282-285
Parole chiave:
pancreas, GNAS mutations
Breve descrizione dei contenuti:
Over 25 years ago, GNAS mutations were discovered associated with McCune-Albright syndrome (MAS) and pituitary tumors. The mutant gene, encoding the heterotrimeric Gs protein, was named 'derived from Gs Protein' (gsp) oncogene. For a long time, gsp remained associated with specific endocrine tumors. Recently, high frequencies of gsp were reported for a rapidly growing number of neoplasms in the gastrointestinal tract. Will heterotrimeric G-proteins follow small G-proteins and become recognized as cancer biomarkers and therapeutic targets?