Pubblicazioni

Denosumab for the Treatment of Mastocytosis-Related Osteoporosis: A Case Series  (2017)

Autori:
Orsolini, Giovanni; Gavioli, Irene; Tripi, Gaia; Viapiana, Ombretta; Gatti, Davide; Idolazzi, Luca; Zanotti, Roberta; Rossini, Maurizio
Titolo:
Denosumab for the Treatment of Mastocytosis-Related Osteoporosis: A Case Series
Anno:
2017
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Referee:
No
Nome rivista:
Calcified Tissue International
ISSN Rivista:
0171-967X
N° Volume:
100
Numero o Fascicolo:
6
Intervallo pagine:
595-598
Parole chiave:
Denosumab; Osteoporosis; RANKL; Systemic mastocytosis
Breve descrizione dei contenuti:
The purpose of this study was to investigate the therapeutic effect of denosumab, an anti-RANKL monoclonal antibody for the treatment of bone loss in indolent systemic mastocytosis (ISM) patients intolerant to bisphosphonates. Four patients underwent upon informed consent a treatment with denosumab 60 mg administered subcutaneously every 6 months with the same regimen used for postmenopausal osteoporosis. Bone mineral density (BMD) was measured at lumbar and femoral sites at baseline and after 1 year. C-terminal telopeptide of collagen type I (CTX), bone alkaline phosphatase (bALP) and tryptase serum level were determined at baseline and after 12 months with fasting blood samples withdrawals. BMD increased significantly at both sites during the 12 months; all the patients had an important decrease of serum CTX and of lesser extent of bALP serum levels. After denosumab treatment, a decrease in serum tryptase level was observed in all the patients. No adverse events or new fractures occurred. Denosumab seems to be a valid alternative for the treatment of bone loss in ISM. RANKL might be of key importance in the pathogenesis of ISM bone involvement.
Id prodotto:
96260
Handle IRIS:
11562/958679
ultima modifica:
2 dicembre 2022
Citazione bibliografica:
Orsolini, Giovanni; Gavioli, Irene; Tripi, Gaia; Viapiana, Ombretta; Gatti, Davide; Idolazzi, Luca; Zanotti, Roberta; Rossini, Maurizio, Denosumab for the Treatment of Mastocytosis-Related Osteoporosis: A Case Series «Calcified Tissue International» , vol. 100 , n. 62017pp. 595-598

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